卡米拉高扎班萨达 (Khamira Gaozaban Sada) 是一种低成本的乌纳尼制剂,可以缓解异二醇和L-NAME诱导的心脏增强工作负荷
Md Adil Shaharyar1, Rudranil Bhowmik1, Arnab Sarkar1
1Bioequivalence Study Centre, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, West Bengal, India.
Current pharmaceutical design
|February 26, 2026
概括
卡米拉高扎班萨达 (KGS) 通过改善心脏功能和结构,有效地保护心脏免受高血压和高. 这种传统的Unani配方在治疗心脏病方面表现有前途,副作用最小.
科学领域:
- 心血管研究研究心血管研究
- 药理学 药理学是指药理学的学科.
- 综合医学是一个整体的医学.
背景情况:
- 心脏缩是对工作量增加的不适应反应,导致心力衰竭和死亡率.
- 传统的Unani配方Khamira Gaozaban Sada (KGS) 正在研究其心脏保护潜力.
- 临床前模型用于评估KGS在高血压和心脏缩中的疗效.
研究的目的:
- 评估KGS在减少心脏工作量和病理重塑方面的有效性.
- 研究KGS心脏保护的潜在机制.
- 评估KGS的安全概况.
主要方法:
- 在L-NAME和ISO诱导的老鼠模型中给出了两剂KGS (1000和2000毫克/公斤).
- 评估了血液动力学,生物化学,组织病理学和心声回声学参数.
- 对H9C2细胞进行了体外研究,CYP抑制测定和代谢物对接.
主要成果:
- 在L-NAME模型中,高剂量的KGS降低了血压和心脏工作量,增强了eNOS表达.
- 在ISO模型中,KGS减弱了心脏缩标志物,改善了心肌组织学,并减少了LV质量.
- 在体外,KGS保护了H9C2细胞免受细胞毒性和过载,并对CYP进行了最小的抑制.
结论:
- 高剂量的KGS提供了对高血压和高的显著心脏保护.
- 通过改善eNOS表达,减少纤维化,氧化应激和过载,KGS起作用.
- 在KGS中的生物活性代谢物向eNOS和β1受体,支持心脏保护的多目标机制.
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