患有近腹和抽的儿童患克罗恩病的风险随着年龄的增长而增加:一个多中心研究
Mariëlle Roskam1, Thomas Dierikx2, Sanne Hulsmann2
1Department of Pediatrics, Emma Children's Hospital, Amsterdam Medical Center, Meibergdreef 9, Amsterdam, The Netherlands.
Journal of pediatric gastroenterology and nutrition
|February 26, 2026
概括
患有周 (PA) 和内 (FIA) 的儿童患克罗恩病 (CD) 的风险为21%,老年儿童的风险更高. 医生应保持对这些患者CD发展的高度意识.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 炎症性肠道疾病研究研究
- 手术儿科手术小儿科
背景情况:
- 周围 (PA) 和内 (FIA) 在儿童中很常见.
- 这些情况可能表明潜在的克罗恩病 (CD).
- 在PA/FIA呈现时的年龄与随后的CD风险之间的关系尚未得到充分理解.
研究的目的:
- 调查PA/FIA与患CD的风险之间的关联.
- 根据孩子在呈现时的年龄来分层这种风险.
主要方法:
- 对患有PA/FIA的2-18岁儿童进行了回顾性多中心研究.
- 收集的数据包括患者特征,生化标志物和CD发育.
- 风险分层根据年龄分为三个子组:<6,6-12岁和12-18岁.
主要成果:
- 在152名患有PA/FIA的儿童中,32名 (21.1%) 被诊断为CD.
- 12-18岁儿童的CD诊断率 (32.4%) 与年轻人相比显著更高.
- 复发的PA/FIA,IBD相关症状和便calprotectin的升高与CD的发展密切相关.
结论:
- 在患有PA/FIA的儿童中,CD的总体风险为21%,并且取决于年龄.
- 医生需要提高对患有PA/FIA的儿童中CD的认识,特别是那些6岁及以上的儿童.
- 对CD的监测至关重要,即使在最初的PA/FIA介绍后的几年里也是如此.
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