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患有超短肠综合征的儿童的当代挑战和结果:描述性队列研究
Hadar Moran-Lev1,2, Samuel A Kocoshis1,3, Mariah Mukasa1
1Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA.
患有超短肠综合征 (USBS) 的儿童需要更多的肠外营养,但与短肠综合征 (SBS) 患者面临的并发症相似. 专业护理可以为USBS儿童带来有利的结果.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 肠道衰竭管理 肠道衰竭管理
- 外科手术的结果
背景情况:
- 超短肠综合征 (USBS) 是短肠综合征 (SBS) 的最严重形式.
- 对于儿科USBS的当代结果数据是有限的.
- 了解USBS管理对于改善患者护理至关重要.
研究的目的:
- 描述患有USBS的儿童的管理经验.
- 评估儿科USBS患者的长期结果.
- 将USBS的结果与标准SBS的结果进行比较.
主要方法:
- 儿科肠衰竭 (IF) 患者 (2018-2022) 的回顾性分析.
- 根据年龄和性别,将USBS患者与SBS对照进行匹配.
- 评估结果包括胆固醇,CLABSI,死亡率,口服厌恶和维生素缺乏.
主要成果:
- 与SBS相比,USBS患者的小肠和大肠长度明显更短.
- 在USBS患者中,有较高的亲肠道营养 (PN) 依赖 (93%对30%).
- 观察到胆固醇和CLABSI的发病率相似;口服厌恶在USBS中更为普遍.
结论:
- 患有USBS的儿童需要更多的PN支持,但与SBS相比,他们有与IF相关的重大并发症率.
- 专业护理与儿科USBS的良好长期结果有关.
- 高水平的维生素缺乏症需要在两组人群中进行持续监测.
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