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Updated: Feb 28, 2026

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

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具有酸-Cis-Diol复合物的粘合性水凝墨水,用于肌肉上印刷.

Jaebeom Lee^1,2, Sumin Lee³, Seung Hyun Lee¹

¹Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Republic of Korea.

Tissue engineering. Part A

|February 26, 2026

概括

研究人员开发了一种新的3D可打印水凝墨水 (PBAink),用于肌肉组织工程. 这种生物粘合材料提供了改善的细胞粘附性和机械性能,在直接肌肉打印应用中优于传统的GelMA油墨.

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科学领域:

生物材料科学生物材料科学
组织工程是组织工程.
再生医学是一种再生医学.

背景情况:

3D打印为肌肉再生提供患者特定的支架.
甲基酸合凝 (GelMA) 是一种常见的3D打印油墨,但具有诸如低粘度,弱力学和组织粘附性差等局限性.
解决这些局限性对于有效的肌肉打印和组织集成至关重要.

研究的目的:

开发一种用于肌肉组织工程的新型可打印和生物粘合水凝墨水 (PBAink).
为了克服现有材料的局限性,例如GelMA用于直接肌肉打印.
创建一个支架,促进肌管对齐和肌肉组织再生.

主要方法:

制造可打印和生物粘合的水凝墨水 (PBAink),使用与酸和甲酸盐 (AlMABA) 结合的酸盐.
优化酸盐缓冲盐水中的盐度,通过cis-diols和phenylborate组之间的动态键增强凝聚力.
评估水凝的特性,包括储存模块,交叉连接速度,胀,生物相容性和组织粘附.
在3D打印的PBAink支架上使用C2C12神经细胞对细胞粘附,扩散,密度和F-actin覆盖的评估.

主要成果:

PBAink显示了类似于肌肉组织的存储模块和快速蓝光交联 (90秒).

关键词:

通过3D打印打印3D打印.细胞粘附细胞粘附在肌肉上打印.组织粘附组织粘附

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与GelMA和甲基酸结合酸盐相比,水凝具有较低的胀,良好的生物相容性和增强的组织粘附性.

PBAink促进了C2C12细胞聚类,扩散,增加了细胞密度,并增强了支架上的F-actin覆盖.

优化的盐度提高了低聚合物度的打印保真度,而光交叉连接确保了结构稳定性.

结论:

PBAink是一种有前途的可打印和生物粘合性水凝油墨,用于肌肉组织工程.
它的特性有助于直接在肌肉上打印,并与肌肉组织结合.
PBAink支持细胞粘附和增殖,为肌肉再生提供了传统基于GelMA的油墨的有效替代品.