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响应pH的超分子系统,激活细胞通道

Gang Song^1,2, Mingyu Li^1,2, Qi Shen¹

¹Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.

ACS applied materials & interfaces

|February 26, 2026

概括

研究人员开发了一个pH响应系统,以激活瘤微环境中的离子通道. 这种有针对性的方法在酸性条件下释放了酸性分子,触发了的流入,并增强了抗瘤免疫力.

科学领域:

生物化学生物化学
分子生物学分子生物学
纳米技术纳米技术

背景情况:

在瘤微环境 (TME) 中精确激活离子通道对于细胞信号传输至关重要,但仍然是一个重大挑战.
现有的方法缺乏按需控制和针对瘤特异性疾病的特异性.

研究的目的:

设计一个pH响应的超分子组件,用于TME中的向离子通道激活.
研究该系统在调节流量和增强抗瘤免疫反应方面的潜力.

主要方法:

开发一种响应pH的超分子组件,使用一种性寡烯烯衍生物 (OPV-hex) 和一种酸可裂解分子 (DMMA).
评估组件的拆卸和OPV-hex在酸性,瘤模仿条件下释放的情况.
电生理学实验和抑制剂研究以确认离子通道激活 (TRPV1,电压导 Ca2+通道) 和流入 (Ca2+).
转录基因分析以评估通路丰富 (亡,信号传递) 和巨细胞极化.

主要成果:

超分子组合有效地在生理pH下屏蔽OPV-hex,并在酸性TME条件下释放它.
释放的OPV-hex向血膜,激活离子通道,并导致瘤细胞和巨细胞显著的Ca2+流入.
证实TRPV1和电压关闭的Ca2+通道参与观察到的流入.
转录组数据显示了亡和与相关的途径的丰富,以及通过巨细胞两极分化增强抗瘤免疫力的潜力.

结论:

成功开发了一种用于pH触发的离子通道调节的新型分子构造驱动策略.
响应pH的系统通过调节离子通道和免疫反应,显示出作为癌症治疗的向平台的潜力.
这种方法为瘤微环境中的细胞信号通路的精确,按需激活提供了一个有希望的途径.

关键词:

结合的寡合体是结合的.离子通道离子通道超分子组合 (Supramolecular Assembly) 是一个超分子组合.瘤治疗疗法瘤治疗 pH 响应性响应性

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