Jove
Visualize
联系我们

相关概念视频

Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

7.9K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
7.9K
Position-effect Variegation02:32

Position-effect Variegation

7.2K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
7.2K
Types of Selection01:46

Types of Selection

45.6K
Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...
45.6K
The Ratio of X Chromosome to Autosomes02:45

The Ratio of X Chromosome to Autosomes

9.9K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.  
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
9.9K
Genetic Lingo01:11

Genetic Lingo

116.2K
Overview
116.2K
Epistasis01:39

Epistasis

50.6K
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
50.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Disease progression is associated with differential neutrophil maturation in Mycobacterium tuberculosis-infected macaques.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

Expanding the clinical spectrum of RNU4ATAC-opathies: more frequent and diverse than assumed.

Genetics in medicine : official journal of the American College of Medical Genetics·2026
Same author

The IL-10/IL-6 Ratio and the Risk Score: Two Cytokines-Based Predictors for Malignancy-Associated Hemophagocytic Lymphohistiocytosis in Adults (M-HLHa).

American journal of hematology·2026
Same author

Impaired kidney function in People with HIV compared to People without HIV.

AIDS (London, England)·2026
Same author

Ultrasensitive Protein Detection Using Luminescent Eu-Ion-Doped Vanadate Nanoparticles.

ACS sensors·2026
Same author

Emerging evidence for anti-PD-1 and IFN-γ as adjunctive immunotherapy in invasive mold infections.

mBio·2026
Same journal

Implications of HIV persistence and pathogenesis in microglia.

Current opinion in HIV and AIDS·2026
Same journal

Paediatric HIV cure section in Current Opinion in HIV and AIDS.

Current opinion in HIV and AIDS·2026
Same journal

Early intervention, lasting impact: benefits of early antiretroviral therapy and implications for posttreatment control.

Current opinion in HIV and AIDS·2026
Same journal

Natural killer cells in pediatric HIV cure strategies: from viral control to immunotherapeutics.

Current opinion in HIV and AIDS·2026
Same journal

Nonhuman primate models of HIV reveal reservoir dynamics and promising interventions.

Current opinion in HIV and AIDS·2026
Same journal

Impact of sex differences in adult and paediatric HIV-1 cure.

Current opinion in HIV and AIDS·2026
查看所有相关文章
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Feb 28, 2026

Using the GAL4-UAS System for Functional Genetics in Anopheles gambiae
06:29

Using the GAL4-UAS System for Functional Genetics in Anopheles gambiae

Published on: April 15, 2021

7.0K

精英控制者现象型的精英控制者.

Nicolas Noel1, Olivier Lambotte

  • 1AP-HP, Hôpital Bicêtre, Service de Médecine Interne et Immunologie Clinique Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological, Bacterial Diseases (IMVA-HB/IDMIT/UMR1184), Le Kremlin Bicêtre, France.

Current opinion in HIV and AIDS
|February 26, 2026
PubMed
概括
此摘要是机器生成的。

艾滋病毒的精英控制者 (EC) 显示出多样化的免疫反应,为持久缓解提供了洞察力. 了解EC异质性是开发有效的HIV治疗策略和个性化治疗方法的关键.

关键词:
艾滋病毒控制器HIV控制器精英控制者 精英控制者免疫激活系统的激活长期的非进步者这里是储水池的储水池.

更多相关视频

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests
08:30

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Published on: September 6, 2024

2.7K
Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

2.6K

相关实验视频

Last Updated: Feb 28, 2026

Using the GAL4-UAS System for Functional Genetics in Anopheles gambiae
06:29

Using the GAL4-UAS System for Functional Genetics in Anopheles gambiae

Published on: April 15, 2021

7.0K
Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests
08:30

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Published on: September 6, 2024

2.7K
Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

2.6K

科学领域:

  • 免疫学 免疫学 免疫学
  • 病毒学 病毒学
  • 传染性疾病 传染性疾病

背景情况:

  • 精英控制者 (ECs) 代表了一种独特的HIV感染者群体,他们可以在没有抗逆转录病毒治疗的情况下自发控制病毒复制.
  • 研究EC对于了解艾滋病毒缓解机制和朝着功能性治疗迈进至关重要.

研究的目的:

  • 审查有关精英控制器表型异质性的新兴数据.
  • 讨论EC特征对艾滋病毒治愈策略和抗逆转录病毒治疗决策的影响.

主要方法:

  • 审查最近的科学文献和对精英控制器的纵向队列研究.
  • 对艾滋病毒储存量大小,免疫反应 (适应性和先天性) 以及临床结果的数据分析.

主要成果:

  • 精英控制器表现出显著的异质性,包括持久性,短暂性和病毒性控制器.
  • 进展包括对HIV储存体的特征以及免疫反应在维护病毒控制中的作用.
  • 纵向数据澄清了病毒控制损失的动态以及非艾滋病定义的并发症的存在.

结论:

  • 精英控制器为持续的艾滋病毒缓解提供了关键的见解,并为以治疗为导向的研究提供了信息.
  • 分层EC表型可以识别接近自发功能治愈的个体.
  • 针对EC的抗逆转录病毒治疗决定需要对病毒学,免疫学和临床因素进行个性化评估.