淋巴细胞-单细胞比率预测了用杜尔瓦卢马布加特雷米利穆马布治疗的HCC患者的生存率
Tomomitsu Matono1, Toshifumi Tada2,3, Atsushi Hiraoka4
1Department of Gastroenterology, Harima Himeji General Medical Center, Himeji, Japan.
概括
淋巴细胞与单细胞的比率 (LMR) 是一种有价值的预后生物标志物,用于接受杜尔瓦卢马布加特雷梅利马布 (Dur/Tre) 的不可切除的肝细胞癌 (HCC) 患者. 较高的LMR与改善无进展生存期 (PFS) 和整体生存期 (OS) 有关.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 生物标志物发现发现
背景情况:
- 肝细胞癌 (HCC) 是一个重要的全球健康问题.
- 无法切除的HCC带来了治疗挑战.
- 杜尔瓦卢马布加上特梅利卢马布 (Dur/Tre) 是无法切除的HCC的治疗选择.
研究的目的:
- 为了研究淋巴细胞与单细胞比率 (LMR) 的预后意义,在无法切除的HCC患者中.
- 评估LMR作为对Dur/Tre.治疗反应的预测生物标志物.
- 为了确定最佳的LMR切断值来预测生存结果.
主要方法:
- 多中心回顾性研究,涉及377名在日本用Dur/Tre治疗的无法切除的HCC患者.
- 时间依赖的接收器运行特征 (ROC) 分析,以确定最佳的LMR切断.
- 危险比率 (HR) 支线曲线分析,以确定最佳的LMR范围,以预测无进展生存 (PFS) 和整体生存 (OS).
主要成果:
- 确定了2.52的LMR切断值,用于预测整体存活率 (OS).
- 较高的LMR (≥2.52) 独立地与优越的PFS (HR:0.777) 和OS (HR:0.657) 相关.
- 在高LMR患者中,与低LMR患者相比,PFS和OS的中位数显著更长 (PFS:3.5与2.6个月;OS:23.4与12.8个月).
- 预测PFS和OS的最佳LMR范围大约为1.8-2.6.6.
结论:
- 淋巴细胞与单细胞的比率 (LMR) 是一个易于获得的预后生物标志物,用于用Dur/Tre.治疗的不可切除的HCC患者.
- 最低限度MR可以预测无进展生存率 (PFS) 和整体生存率 (OS).
- 在临床实践中,LMR作为风险分层的实际工具.
更多相关视频
相关概念视频
Treatment Resistant Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...


