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Updated: Jun 20, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
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Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

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针对复发性/耐药性霍奇金淋巴瘤的基于抗编程细胞死亡蛋白1的救援疗法:一个多中心的现实世界分析

Hishan Tharmaseelan1, Lisa M Sgonina2, Ina Bühnen1

  • 1University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine; Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD); and German Hodgkin Study Group (GHSG), Cologne.

Haematologica
|February 26, 2026
PubMed
概括

自主干细胞移植前使用PD-1抑制剂的救生疗法对复发/耐药霍奇金淋巴瘤患者显示出有前途的结果. 这种方法提供了很好的生存率,支持其在临床实践中的使用.

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...