孕产妇甲状腺功能低下症对人乳中宏观营养素含量和脂肪酸成分的影响:一项前性队列研究
Shahad Alodhaybi1, Manal Abdulaziz Binobaed1, Rasha Homoud AlAnazi2,3
1Department of Food Science and Nutrition, King Saud University, Riyadh, Saudi Arabia.
Frontiers in nutrition
|February 26, 2026
概括
孕产妇的甲状腺功能低下会改变人乳脂肪酸的成分,对omega-3,omega-6和trans脂肪酸的具体变化. 这些发现突出了对婴儿营养的潜在影响,并建议进一步研究针对性的干预措施.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 生物化学 生物化学
背景情况:
- 甲状腺功能低下症可能会影响母亲的血清脂质样本和人乳 (HM) 蛋白质成分.
- 研究母体甲状腺功能低下症对HM大营养素和脂肪酸 (FA) 含量的影响对于了解婴儿营养至关重要.
研究的目的:
- 检查母亲甲状腺功能低下症与母乳 (HM) 的宏观营养素含量和脂肪酸 (FA) 组成之间的关联.
主要方法:
- 一项前性队列研究比较了来自低甲状腺症和没有低甲状腺症的母亲的HM样本.
- 用专门的分析仪和气体染色学分析了HM样本的宏观营养素含量和FA成分.
- 还评估了母亲的特征,饮食摄入量和脂质概况.
主要成果:
- 两组之间没有观察到HM宏观营养素含量或总和,单不和,多不和和跨脂肪酸 (TFAs) 的显著差异.
- 然而,在甲状腺功能低下症的母亲中,有10种单独的FA物种存在显著差异,包括更高的工业TFAs,omega-3和omega-6物种.
- 患有甲状腺功能低下症的母亲表现出较高的多可萨氨酸和埃莱德酸,较低的三可萨酸水平,以及较高的LDL胆固醇.
结论:
- 孕产妇的甲状腺功能低下与改变的HM FA组成有关,可能是由于甲状腺激素介导的脂质代谢变化.
- 这些变化可能受到母亲的饮食和脂肪组织储存的影响.
- 需要进一步的研究来探索甲状腺意识的哺乳支持和营养干预措施,以优化母乳养结果.
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