高密度脂蛋白胆固醇与代谢功能障碍相关的脂肪性肝病之间的非线性关系:在日本人口中进行的横截面研究
Xiang Guo1, Yucong Zou1, Cui Yang2
1Department of Rehabilitation, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China.
Frontiers in medicine
|February 26, 2026
概括
高密度脂蛋白胆固醇 (HDL-C) 在日本成年人中显示出与代谢功能障碍相关的脂肪性肝病 (MASLD) 的反向,非线性联系. 超过1.04mmol/L的水平显著降低了MASLD风险,突出了保护值效应.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 有限的研究存在于高密度脂蛋白胆固醇 (HDL-C) 对代谢功能障碍相关的脂肪性肝病 (MASLD) 的影响.
- 了解这种关系对于管理肝脏健康和代谢综合征至关重要.
研究的目的:
- 调查HDL-C水平与日本人口中MASLD患病率之间的相关性.
- 为了确定HDL-C对MASLD风险的潜在非线性关联和值效应.
主要方法:
- 对14280名患者的健康记录进行了回顾性分析.
- 用二进制逻辑回归和通用添加模型 (GAM) 评估线性和非线性关联.
- 一个由两部分组成的后勤回归模型确定了一个关键的高密度脂肪-C值.
主要成果:
- 在HDL-C水平和MASLD患病率 (OR=0.46) 之间发现了反向相关性.
- 确定了显著的非线性关系,临界的HDL-C值为1.04 mmol/L.
- 在1.04mmol/L以上,增加的HDL-C与MASLD的可能性降低了61% (OR=0.39),而在这个门以下,这种联系是逆转的 (OR=1.49).
结论:
- 在日本人群中,HDL-C和MASLD之间存在一个反向的,非线性关系.
- 过高的HDL-C水平超过1.04mmol/L显示出对MASLD的显著保护作用.
- 这项研究强调了HDL-C在减轻MASLD风险方面的值效应.
相关概念视频
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
244
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
244
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
302
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
302
Cholesterol: Significance and Regulation
1.7K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
1.7K
Overview of Lipid Metabolism
6.1K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
6.1K
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
1.6K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.6K
Blood Studies for Cardiovascular System III: Serum Lipid Profile
705
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
705


