病例报告:一种罕见的ANCA阳性Q热病例,与内心炎相关的血球炎
Qian Li1, Suwen Liu1, Jing Wang1
1Department of Pediatric Nephrology and Rheumatism and Immunology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Frontiers in medicine
|February 26, 2026
概括
Q热内心炎是一种罕见的儿童疾病,可能导致脏损伤. 这一案例突出显示,一名中国男孩患有Q热内心炎相关的球球核炎和阳性PR3-ANCA抗体.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 热是一种全球性的动物传播性疾病,由*Coxiella burnetii*引起.
- Q热内心炎在儿童中不常见,但可能导致脏损伤.
- 本报告详细介绍了一例患有Q热内心炎相关的血球炎病例,该病例发生在患有阳性抗蛋白酶3抗体 (PR3) - 抗菌素细胞质抗体 (ANCA) 的儿科患者身上.
研究的目的:
- 为了在儿童中呈现罕见的Q热内心炎相关的Q热血球炎.
- 强调在患有特定临床表现和血清学发现的儿科患者中考虑Q热内心炎的重要性.
- 为了突出这种情况的诊断方法.
主要方法:
- 一个有先天性心脏病史的12岁男孩出现了持续的发烧和出血.
- 诊断工作包括血清测试 (菌质体,EBV,ANCA面板),下一代基因组测序 (mNGS),心脏超声波和活检.
- 治疗包括多西环林治疗Q热.
主要成果:
- 该患者有阳性PR3-ANCA抗体,并通过mNGS和免疫光测定检测到*Coxiella burnetii*.
- 心脏超声波显示了肺膜上的植被,与内心炎一致.
- 脏活检表明了二次性超级增生性球球蛋白质神经炎. 用多西环林治疗消除了发烧和出血症.
结论:
- 在患有慢性发烧,出血和阳性ANCA的儿童中,应该怀疑Q热内心炎,特别是患有先天性心脏病的儿童.
- 诊断工具如mNGS,心脏超声波和活检对于诊断至关重要.
- 早期识别和治疗可以预防严重的并发症.
关键词:
在Q型发烧中,Q型发烧抗中性粒细胞体抗体是抗中性粒细胞体抗体.孩子孩子孩子孩子孩子孩子心内膜炎是一种心内膜炎.球体隆基尼弗里斯 (glomerulonephritis) 是一种发生在人体中的疾病.更多相关视频
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