在急性胃肠道损伤的危急病患者中,基于连续的标准聚合物肠道营养配方与连续的标准聚合物肠道营养配方:单中心,并行组随机对照试验的研究协议
Yanhua Li1, Youquan Wang1, Ying Chen1
1Department of Critical Care Medicine, The First Hospital of Jilin University, Changchun, China.
Frontiers in medicine
|February 26, 2026
概括
对于患有急性胃肠道损伤 (AGI) 的重症患者,本研究将持续使用基于的肠道配方 (PBF) 与在胃肠功能改善后切换到标准聚合物配方 (SPF) 的情况进行比较. 结果将指导最佳的营养支持策略.
科学领域:
- 关键护理医学 关键护理医学
- 临床营养学 临床营养学
- 胃肠病学 胃肠病学
背景情况:
- 基于的肠道配方 (PBF) 最初可能有利于患有急性胃肠道损伤 (AGI) 的重症患者.
- 在AGI改善后,最佳的肠道配方选择仍然不清楚.
研究的目的:
- 为了比较持续使用PBF的疗效和安全性与转换到标准聚合物配方 (SPF) 在重症患者的AGI.
- 在改善胃肠功能的患者中,从第4天开始评估营养支持策略.
主要方法:
- 一个单中心的随机对照试验,分配1:1和治疗意图分析.
- 将包括496名患有AGI I-II级的成年危急病患者.
- 干预包括持续的PBF或在ICU第4天切换到SPF,根据AGI等级.
主要成果:
- 主要结局:第7天的平均每日能量摄入量 (千卡/千克/天).
- 二次结果和流程措施将根据每个协议进行评估.
- 治疗意图分析提高了结果的稳定性.
结论:
- 这项研究将为重症患者的胃肠功能恢复提供关于最佳肠道配方策略的证据.
- 研究结果旨在优化营养管理和重症监护机构患者的治疗结果.
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