重新评估GLP-1受体激动剂的癌症风险:胃肠道恶性瘤的综合元分析
Adil Farooq Wali1, Imran Rangraze2, Shehla Khan3
1RAK College of Pharmacy, RAK Medical and Health Sciences University, Ras AlKhaimah, United Arab Emirates.
Frontiers in pharmacology
|February 26, 2026
概括
类似葡萄糖-1受体激动剂 (GLP-1RA) 不会增加胃肠道癌症的风险. 这次元分析发现,整体风险没有增加,结直肠和肝癌发病率的潜在降低,支持它们的安全使用.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 类似葡萄糖-1受体激动剂 (GLP-1RA) 是对2型糖尿病 (T2DM) 和肥胖的常见治疗方法.
- 有关GLP-1RA使用与胃肠道 (GI) 癌症之间的潜在关联存在担忧.
研究的目的:
- 调查GLP-1RA使用与患胃肠道癌的风险之间的关联.
- 为继续安全处方GLP-1RA提供基于证据的见解.
主要方法:
- 一个系统的审查和随机对照试验 (RCTs) 的元分析发表到2024年8月.
- 包括93个涉及185万参与者的RCT,分析聚合危险比率 (HRs) 和置信区间 (CI).
- 根据癌症类型和GLP-1RA暴露的持续时间进行了子组分析.
主要成果:
- GLP-1 RA使用与肠道癌的整体风险增加无关 (HR 0.81;95% CI:0.68-0.96).
- 结直肠癌 (HR 0.81; 95% CI: 0.68-0.96) 和肝癌 (HR 0.74; 95% CI: 0.62-0.88) 的风险有所降低.
- 没有发现胰腺癌风险显著增加 (HR 0.78;95% CI:0.61-0.95).
结论:
- 这一元分析表明GLP-1RA与增加的胃肠道癌症风险无关.
- 对结直肠和肝癌发病率的潜在降低需要谨慎解释和进一步调查.
- 这些发现支持GLP-1RA在T2DM和肥胖管理中继续安全使用.
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