发酵的中国传统药物中乳杆菌的抗GPV活性
Hongrui Chen1,2, Songrui Liu1,2, Qiuxuan Wang1,2
1College of Life Sciences, Jilin Agricultural University, Changchun, Jilin, China.
Frontiers in microbiology
|February 26, 2026
概括
发酵传统中医药与植物乳杆菌增强其抗病毒性质对子帕维病毒 (GPV). 这一过程增加了活性化合物,为GPV治疗和改善肠道健康提供了有希望的方法.
科学领域:
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
- 兽医医学 兽医医学 兽医医学
背景情况:
- 蜜和花是已知抗病毒功能的中国传统医药 (TCM).
- 酸和花园酸是这些草药中的关键生物活性化合物.
- 有限的研究存在于TCM的微生物发酵用于抗病毒应用.
研究的目的:
- 调查发酵TCM对子帕维病毒 (GPV) 的抗病毒活性.
- 探索从料中分离出来的 Lactobacillus,用于TCM发酵.
- 评估发酵TCM在抗病毒治疗中的理论和实践价值.
主要方法:
- 隔离和识别的植物乳杆菌.
- 使用基于细胞的试验 (CCK-8,qPCR) 进行体外抗病毒活性评估.
- 高性能液体色谱 (HPLC) 用于分析活性成分.
- 网络药理学和分子对接以阐明机制.
主要成果:
- 隔离的Lactobacillus plantarum菌株显示出高耐受性和安全性.
- 细菌代谢物和发酵的TCM在体外显著抑制了GPV的扩散.
- 发酵增加了酸和花园酸的含量.
- 发酵TCM显示出显著的抗GPV效应.
结论:
- 植物乳杆菌和发酵的TCM有效地对抗GPV感染.
- 发酵增强了TCM活性成分的抗病毒和抗炎作用.
- 潜在的协同作用机制包括IL-6/TNF信号通路的调节和肠道微生物群的相互作用.
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