血循环瘤脱氧核糖酸变化与肝细胞癌患者的存活率之间的相关性分析
Songtao Liu1, Jingjing Chen1, Qiaoxin Wei1
1Department of Oncology, Beijing You'an Hospital, Capital Medical University, Beijing, China.
Frontiers in oncology
|February 26, 2026
概括
循环瘤DNA (ctDNA) 分析显示,瘤突变负担 (TMB) 与肝癌的整体存活率 (OS) 有关. 特定的基因突变,如LRP1B,对接受全身治疗的患者的生存率产生影响.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
背景情况:
- 肝细胞癌 (HCC) 是一个主要的全球健康问题.
- 准确的预后标记对于有效的HCC管理至关重要.
研究的目的:
- 在HCC患者中分析循环瘤DNA (ctDNA) 变异.
- 为了确定预测HCC预后和治疗反应的潜在生物标志物.
主要方法:
- 有望招募166名新诊断的HCC患者.
- 血ctDNA测试,临床数据,治疗和生存数据的收集.
- 对瘤突变负担 (TMB) 和特定基因突变 (例如TP53,CTNNB1,LRP1B) 的分析.
主要成果:
- TMB与巴塞罗那诊所肝癌 (BCLC) 阶段相关.
- TP53和LRP1B突变与更短的存活时间有关.
- 在接受全身治疗的患者中,LRP1B突变显著降低了整体存活率 (OS).
结论:
- ctDNA分析,特别是TMB,是HCC预后的宝贵工具.
- 在接受全身治疗的HCC患者中,LRP1B突变可能预测不良结果.
- ctDNA作为评估HCC患者结果的生物标志物具有潜力.
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