相关实验视频

Updated: Feb 28, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

纳米技术驱动的移植免疫的精确调制:从机械洞察到临床耐受性

Long Zhang^1,2,3, Kunzhe Wu^1,2,3, Shuhan Si⁴

¹Department of Urology, Second Ward, China-Japan Union Hospital of Jilin University, Changchun, 130033, People's Republic of China.

International journal of nanomedicine

|February 26, 2026

概括

纳米技术为器官移植提供有针对性的免疫调节,克服排斥并改善结果. 这种方法承诺精确控制免疫微环境,解决当前免疫抑制的局限性.

科学领域:

免疫学免疫学免疫学
生物技术是生物技术.
材料科学材料科学材料科学

背景情况:

器官移植是器官衰竭的重要治疗方法,但面临着免疫排斥和广泛的免疫抑制副作用的挑战.
传统的免疫抑制剂缺乏特异性,导致感染,恶性瘤和无法有效调节当地的免疫环境.

研究的目的:

系统地审查纳米技术与移植免疫调节的整合.
分析免疫排斥的机制,并将纳米平台与常规免疫抑制剂进行比较,以精确调节免疫力.

主要方法:

免疫排斥机制的划定,包括免疫微环境,T细胞,巨细胞和氧化应激在缺血-再输液损伤 (IRI) 中的作用.
传统免疫抑制剂和基于纳米平台的针对性免疫调节策略的批判性比较.
探索纳米技术在重新编程免疫细胞,减轻氧化应激和促进组织修复方面的应用.

主要成果:

纳米技术可以实现有针对性的输送,多功能协同作用,以及在移植中对刺激有反应的免疫调节.
纳米平台可以精确地准移植的免疫微环境,重编程免疫细胞功能,并减少氧化应激.
纳米技术促进组织修复,再生和免疫耐受性诱导,在器官冷保存中具有潜在的应用.

结论:

纳米技术为移植免疫调节提供了一种有针对性的,多功能和持续的方法.
仍然存在重大翻译挑战,但跨学科的整合将促进器官移植中的精确免疫调制.

关键词:

免疫排斥免疫排斥免疫耐受性免疫耐受性免疫抑制是一种免疫抑制.纳米药物输送提供服务.纳米技术是纳米技术.移植免疫力移植免疫力

更多相关视频

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

相关概念视频

Cell-mediated Immune Responses

Cell-mediated Immune Responses

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...