用于伤口治疗和组织修复的生物基粘合水凝:从材料到先进的应用
Dongyang Miao1, Yige Gao1, Bowen Shi1
1State Key Laboratory for the Development and Utilization of Forest Food Resources, Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, China.
APL bioengineering
|February 26, 2026
概括
生物基粘合剂水凝提供优越的湿组织粘附性和生物相容性,用于伤口修复. 这些智能材料对刺激有反应,可实现先进的按需医疗治疗,克服传统粘合剂的局限性.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 聚合物化学 聚合物化学
背景情况:
- 在潮湿,动态的生理条件下有效的组织粘附是伤口管理的关键挑战.
- 传统的组织粘合剂往往具有较差的生物相容性,较弱的湿粘度或缺乏可降解性,限制了临床应用.
- 生物基粘合水凝是一种有希望的替代品,因为它们的生物相容性,可调节性质和在生物环境中强大的粘合性.
研究的目的:
- 审查最近生物基粘合水凝用于组织修复的进展.
- 强调材料设计,粘附机制,评估方法和生物医学应用.
- 为设计和翻译下一代生物基粘合剂水凝提供指导.
主要方法:
- 关于生物基粘合剂水凝的文献综述.
- 对材料设计策略和界面粘附机制的分析.
- 讨论评估方法和生物医学应用.
主要成果:
- 生物基水凝在潮湿条件下表现出可调节的机械性能和强大的粘附性.
- 响应刺激的水凝提供了多功能和按需处理能力.
- 这些材料有效地解决了湿组织粘附,机械不匹配和动态接口方面的挑战.
结论:
- 生物基粘合水凝是治疗伤口和组织修复的先进材料.
- 未来的方向包括克服翻译挑战和整合多功能性以实现临床实用性.
- 持续的研究将推动创新,最少侵入性医疗治疗的发展.
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