适当的碳烯治疗的限制评估 (REACT):一个多站点的观察性研究
Drew A Wells1,2,3, Madison McKnight4, Jessica Jaggar1,2
1Department of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA.
概括
实施美罗胺限制标准显著减少了卡巴胺抗生素的使用和五家医院的支出. 这种抗菌药物管理策略在优化美罗的利用和控制成本方面被证明是有效的.
科学领域:
- 传染性疾病 传染性疾病
- 抗微生物药物管理委员会
- 医疗保健服务研究 医疗服务研究
背景情况:
- 过度使用卡巴胺抗生素有助于患者的不良影响和抗菌素耐药性.
- 有效的抗菌药物管理计划对于优化医疗保健环境中的抗生素使用至关重要.
研究的目的:
- 评估美罗胺限制标准对利用量和适当性的持续影响.
- 评估美罗胺限制对多医院医疗系统中药物开支的影响.
主要方法:
- 一项回顾性观察性研究分析了在限制标准实施前和之后在5家成人医院的美罗胺订单.
- 研究人员比较了梅罗胺治疗日/1000个患者日 (DOT/1000个PD) 和药物支出的数据.
- 统计分析包括t测试,曼-惠特尼U测试,奇平方和费舍尔精确测试 (P <0.05).
主要成果:
- 39%的美罗胺订单是不合适的,常见原因包括青素过敏记录和过早开始.
- 梅罗胺中位数DOT/1000 PD显著下降,从40.5降至20 (P < 0.001).
- 在整个卫生系统中,月均美罗胺药物消费量下降了42% (P = 0.001).
结论:
- 梅罗胺限制标准有效和可持续地减少了卡巴胺的使用和相关的医疗保健成本.
- 这些标准支持在多个地点的卫生系统中继续采用抗微生物药物管理政策.
- 这些发现强调了有针对性的干预措施在优化抗生素处方实践方面取得的成功.
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