费内伦对2型糖尿病脏病患者功能的影响:一项回顾性队列研究
Xu-Ying Liu1, Ya-Min Zhao1, Ya-Guang Zhang2
1Department of Endocrinology, Affiliated Hospital of Hebei University, Baoding, Hebei, China.
Frontiers in endocrinology
|February 26, 2026
概括
添加finerenone到标准治疗改善了糖尿病病患者的功能. 这种组合疗法可以降低显著功能下降的风险,而不会增加不良事件.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 糖尿病病 (DN) 是慢性病 (CKD) 的主要原因,尽管目前的治疗方法.
- 优化氨酸-血管激素系统 (RAS) 阻塞是标准的护理,但对于许多DN患者来说是不够的.
研究的目的:
- 评估DN患者在ACEI/ARB治疗中添加芬的疗效和安全性.
- 在这个人群中确定临床意义上的脏恶化预测因素.
主要方法:
- 对240名成人DN患者 (2019-2024) 的回顾性队列研究.
- 与ACEI/ARB单疗法 (n=124) 与ACEI/ARB加上精氨 (n=116) 进行了24周的比较.
- 分析了的参数 (Scr,eGFR,UACR) 并使用逻辑回归来确定预测因子.
主要成果:
- 在24周后,费内伦组显示血清肌素显著降低,eGFR高,尿动白蛋白与肌素比率 (UACR) 降低.
- 费内伦治疗独立地与预防功能恶化有关 (aOR=0.473,P=0.019).
- 糖尿病持续时间较长,基线eGFR较低,UACR较高预测eGFR下降.
结论:
- 在ACEI/ARB疗法中添加费内伦可以改善DN患者的参数.
- 菲内伦显著降低了临床意义上的eGFR下降的风险.
- 组合疗法耐受性良好,没有增加严重高血或不良事件的风险.
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