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主体特征和环境因素影响了野生鼠原生菌网络中的感染异质性
Matan Markfeld1, Itamar Talpaz1, Barry Biton1
1Department of Life Sciences, Ben-Gurion University of the Negev, Be'er-Sheva, 8410501, Israel.
ISME communications
|February 26, 2026
概括
黑鼠 (Rattus rattus) 的微生物感染非常多样,受宿主特征和环境的影响. 宿主体质量和肠道微生物组是感染概况的关键预测因素,影响疾病生态.
科学领域:
- 微生物生态学 微生物生态学
- 疾病生态学 疾病生态学
- 主体-微生物相互作用
背景情况:
- 动物宿主中的微生物感染是异质的,受宿主特征,环境和微生物多样性的影响.
- 了解感染异质性对于内寄生虫感染,疾病传播和溢出风险至关重要,特别是在野生系统中.
- 在个体宿主水平上驱动感染异质性的机制尚不清楚.
研究的目的:
- 在马达加斯加引入的黑鼠 (Rattus rattus) 中调查原生动物感染异质性的驱动因素.
- 开发一个框架,以了解野生宿主群体内原生动物丰富性和组成的变化.
- 确定宿主特征和环境因素在预测感染概况方面的相对贡献.
主要方法:
- 利用基于网络的随机区块建模来识别不同的原生动物感染概况.
- 采用机器学习模型,利用宿主特征和环境变量预测感染概况.
- 在马达加斯加的环境梯度中分析了黑鼠中的原生动物感染.
主要成果:
- 根据原生动物的丰富性和组成,确定了三种不同的感染特征.
- 主体特征,特别是身体质量和肠道微生物组合,是比环境因素更强的预测因素 (40%以上).
- 鼠和其他非本地物种的密度是最有影响力的环境预测因素.
结论:
- 黑鼠的感染异质性来自内在宿主特征与外在环境条件之间的相互作用.
- 网络分析和预测建模的综合方法有效地揭示,解释和预测宿主感染异质性.
- 这一框架促进了微生物和疾病生态学的发展,有助于了解人与动物接口上的动物性传染病原体循环.
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