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Updated: Feb 27, 2026

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对前列腺癌的衰老和免疫功能的图书统计洞察:专注于慢性炎症

Shaohong Lai¹, Chongsen Lin², Lujing Li³

¹Department of Urology, Kidney and Urology Center, the Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, People's Republic of China.

Journal of inflammation research

|February 26, 2026

概括

这项研究分析了关于前列腺癌 (PCa) 衰老,免疫功能和慢性炎症的研究. 研究结果强调慢性炎症是将衰老与PCa进展和治疗耐药性联系起来的关键因素.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
老年学是指老年学的学科.

背景情况:

前列腺癌 (PCa) 的进展受到与衰老相关的免疫功能障碍和慢性炎症的显著影响.
慢性炎症是衰老,免疫变化和PCa发育,进展和治疗耐药性之间的关键联系.

研究的目的:

在PCa中对衰老,免疫功能和慢性炎症的研究进行文献分析.
确定这一领域的关键研究趋势,主要贡献者和新兴的治疗策略.

主要方法:

从Web of Science核心集合 (2015-2025) 中对1556篇出版物的图书统计分析.
使用VOSviewer,CiteSpace和Bibliometrix来分析出版趋势,协作和关键字的共同出现.
专注于与衰老相关的分泌表型 (SASP) 因素,炎症生物标志物和与衰老相关的PCa中的免疫功能障碍.

主要成果:

研究的显著增长,美国,中国和意大利是主要贡献者.
关键主题包括SASP因素,氧化应激,免疫逃避以及IL-6和TMB等生物标志物.
新兴策略包括SASP向,CAR-T细胞免疫疗法和组合疗法.

结论:

图书统计分析提供了一个全面的研究概述,在PCa的衰老,免疫和炎症的交叉点.
慢性炎症被确定为一个中心和不断发展的研究重点.
这些发现为未来的机制和转化研究提供了框架,以改善PCa疗法.

关键词:

老化的老化衰老的老化文献计量分析的分析细胞衰老细胞衰老慢性炎症是一种慢性炎症.免疫功能免疫功能免疫功能前列腺癌是前列腺癌.

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