与多发性骨髓瘤患者的静脉血栓栓塞相关的临床因素,这些患者接受了达拉图穆巴治疗
Naveen G Subramanian1, Fleur M Aung2, Zachary E Hunzeker1
1Internal Medicine Residency, UTHealth McGovern Medical School, Houston, TX USA.
Discover medicine
|February 26, 2026
概括
静脉血栓塞栓症 (VTE) 是多发性骨髓瘤 (MM) 患者接受达拉图穆马布治疗的常见病例. 风险因素包括多次中央静脉导管插入和并发症,突出显示需要谨慎监测.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床医学 临床医学
背景情况:
- 静脉血栓塞栓症 (VTE) 是多发性骨髓瘤 (MM) 患者患病和死亡的重要原因.
- 有限的证据存在于与VTE相关的因素在达拉图巴基疗法期间.
研究的目的:
- 为了调查与VTE发展相关的临床,药物和程序相关的因素,在MM患者治疗daratumumab.
主要方法:
- 对MM患者的回顾性图表审查,这些患者接受了含达拉图巴的治疗方案.
- 临床因素,癌症治疗,抗血栓药物和中央静脉接入程序的分析.
- 进行了单变量和多变量逻辑回归分析.
主要成果:
- 在接受达拉图姆巴的MM患者中,在12个月后,VTE的发病率为9.6%.
- 多重外围插入的中央导管 (PICC) 线插入和众多的医学并发症与静脉瘤发展有关.
结论:
- 在MM治疗期间,VTE经常发生,特别是在多次PICC线插入和最近感染的情况下.
- 该研究的回顾性设计和有限的VTE事件需要进一步调查.
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