基于毒性途径的草甘诱导女性生殖毒性的不良结果途径框架的构建
Bixia Peng1, Daniel Schlenk2, Jing Liu1
1MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.
Environment & health (Washington, D.C.)
|February 26, 2026
概括
基于草甘的除草剂 (GBHs) 通过影响激素受体和线粒体来破坏女性生殖,导致卵巢和子宫内膜问题. 本综述使用不良结果途径 (AOP) 框架来详细说明这些毒性影响.
科学领域:
- 环境毒理学环境毒理学
- 生殖毒理学 生殖毒理学
- 内分泌学 在内分泌学.
背景情况:
- 草甘 (GLY) 是一种在全球范围内广泛使用的除草剂,包括在人体组织中.
- GLY及其配方 (GBHs) 被怀疑是影响女性生殖的内分泌干扰剂.
- 现有证据表明,GLY/GBH通过各种机制对生殖健康产生不利影响.
研究的目的:
- 审查和综合当前关于GLY/GBHs诱导的女性生殖毒性的知识.
- 通过不良结果路径 (AOP) 框架,阐明多个生物水平中毒性的机制.
- 为风险评估和环境管理建立因果关系.
主要方法:
- 文献综述综合了GLY/GBH和女性生殖毒性的数据.
- 应用不良结果路径 (AOP) 框架,将分子启动事件 (MIE) 映射到不良结果.
- 构建一个AOP网络以说明因果关系.
主要成果:
- 确定了三个关键的MIEs:ERα激活,芳酶抑制和线粒体复合物的破坏.
- 与关键事件相关的MIEs包括氧化应激,DNA损伤和表观遗传修饰.
- 记录了组织/器官水平的影响,如荷尔蒙失衡,受损的卵子发生和子宫内膜增生,导致诸如早产卵巢衰竭和子宫内膜癌等疾病.
结论:
- 该AOP框架提供了对GLY/GBHs女性生殖毒性的全面了解.
- 建立了从分子事件到临床结果的因果关系.
- 确定了监管决策和公共卫生保护的潜在生物标志物和干预目标.
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