前列腺特异性抗原速度作为前列腺癌患者生存结果的预测指标:一个元分析
Feilun Cui1,2, Yueshi Zhang3, Ziyan Liu3
1Department of Urology, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Frontiers in oncology
|February 26, 2026
概括
提升的前列腺特异性抗原速度 (PSAV) 显著预测前列腺癌患者的死亡率. 这一元分析证实PSAV是生存结果的关键生物标志物,有助于风险分层.
科学领域:
- 在瘤学瘤学.
- 生物标志物发现发现
- 预测因素 预测因素
背景情况:
- 前列腺特异性抗原速度 (PSAV) 是预测前列腺癌生存率的新兴生物标志物.
- 准确预测生存结果对于管理前列腺癌患者至关重要.
研究的目的:
- 进行一项元分析,评估PSAV与全因死亡率和前列腺癌特定死亡率 (PCSM) 之间的关联.
- 评估PSAV在前列腺癌存活率中的预后价值.
主要方法:
- 在主要的电子数据库中进行了全面的文献搜索,截至2025年3月1日.
- 包含的研究报告了基于分类PSAV分析的生存结果的95%置信区间 (CI) 的调整危险比率 (HR).
- 用随机效应模型计算聚合HR,以解决临床异质性问题.
主要成果:
- 分析包括11项研究,涉及3713名前列腺癌患者.
- 升高的PSAV与所有原因死亡率 (HR 1.96;95% CI 1.33-2.88) 和PCSM (HR 5.38;95% CI 2.76-10.51) 的增加显著相关.
- 分层分析显示,局部疾病的所有原因死亡率的汇总HR为1.91 (95% CI 1.43-2.55),而转移性疾病的1.26 (95% CI 0.41-3.84).
结论:
- 升高的PSAV是前列腺癌患者死亡率的重要预测因素.
- 测量PSAV可能有助于预测生存结果.
- 为了在不同人群中标准化PSAV测量和验证,需要进一步的研究.
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