肠道衰竭儿童的营养摄入量和生长:一个探索性横截面研究
Naoko Inamura1,2, Miyuki Takeda3, Manami Sasaki3
1Department of Pediatric Surgery, Tohoku University Graduate School of Medicine, Japan.
Intestinal Failure (New York, N.Y.)
|February 26, 2026
概括
患有肠衰竭 (IF) 经历生长障碍 (GI) 的儿童往往缺乏足够的脂质和蛋白质摄入量. 优化营养比例对于儿科IF患者的适当生长至关重要.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 营养科学 营养科学
- 临床研究 临床研究
背景情况:
- 增长障碍 (GI) 是患有肠衰竭 (IF) 的儿童的一个问题.
- 在儿科IF患者中,与肠道肠道关联的因素尚未得到充分确立.
- 假设营养摄入量会影响GI在这个人群中.
研究的目的:
- 调查IF儿童的营养摄入量和生长障碍之间的关联.
- 为了比较GI和没有GI的儿童之间的营养参数.
主要方法:
- 19名儿童患者 (2-16岁) 接受家庭上肠道营养 (PN) 被分为 (GI+) 或没有 (GI-) 增长障碍的组 (身高对年龄z-score ≤ -2).
- 比较包括PN依赖,小肠残留长度 (RSIL) 和摄入卡路里,蛋白质,脂质和碳水化合物.
- 营养素摄入量被评估为推摄入量的百分比.
主要成果:
- 在GI+组显示显著更高的PN依赖 (109.8%对61.7%).
- 在GI+组中,脂质摄入率较低 (11.9%vs17.5%),碳水化合物摄入率较高 (76.8%vs66.8%).
- 在GI+组中,脂质充足率明显较低 (37.5%对89.6%),而蛋白质摄入量较低,但充足率在两组中均保持高 (>100%).
结论:
- 与能量需求相对较低的蛋白质和脂质摄入比可能会抑制FI儿童的生长.
- 营养管理,特别是优化脂质和蛋白质摄入量,对于儿科IF的生长至关重要.
- 需要进一步研究特定营养缺乏及其对IF生长的影响.
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
972
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
972
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
1.3K
Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
1.3K
Enteral Nutrition I: Orogastric and Nasogastric Feeding
1.9K
Enteral nutrition delivers nutrients directly to the stomach or small intestine through a tube. This method is appropriate for patients who cannot eat but still have a functioning digestive system. It is also beneficial for individuals with swallowing difficulties, anorexia, malabsorption, or those who have undergone gastrointestinal (GI) surgery.
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
1.9K
Anatomy of the Intestines
88.6K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
88.6K
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
377
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
377


