在瘤实践中对脏免疫相关不良事件的紧急考虑
Wen-Qing Lv1,2, Jing-Yao Lu2, Jun Li1,2
1Department of Nephrology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.
Frontiers in immunology
|February 26, 2026
概括
免疫检查点抑制剂 (ICI) 可以在癌症患者中引起脏问题 (脏irAEs). 本综述涵盖了性irAEs的原因,生物标志物和管理策略,特别是在慢性病患者中.
科学领域:
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 在癌症治疗中至关重要,但可能导致与免疫相关的不良事件 (irAEs).
- 脏irrAEs是一个重大问题,往往导致治疗停止和影响瘤进展.
- 对癌症患者来说,管理脏IRAEs至关重要,特别是那些已经患有慢性病 (CKD) 的人.
研究的目的:
- 系统地审查ICI诱导的病的免疫病因.
- 为了确定敏感性基因,非侵入性生物标志物,以及对脏irAEs的有效干预策略.
- 分析瘤学家在癌症患者中管理脏IRAE的关键考虑因素,包括移植接受者和ESRD患者.
主要方法:
- 系统的文献审查.
- 对CKD癌症患者ICI治疗的现实世界证据的分析.
- 检查与脏irAEs相关的免疫机制,遗传因素和生物标志物.
主要成果:
- 通过复杂的免疫路径,ICI可以诱导各种形式的损伤.
- 特定的遗传因素可能会影响对脏irAEs的敏感性.
- 对于早期检测和监测脏irAEs,需要非侵入性生物标志物.
- 管理策略包括仔细选择患者,监测和及时干预.
结论:
- 在癌症患者,尤其是患有慢性瘤患者中,脏性IRAE构成了重大挑战.
- 对瘤学家来说,全面了解病变发生,生物标志物和管理是必不可少的.
- 针对性免疫治疗的进步可能会改善癌症患者的结局和存活率.
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