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作为独立的心血管风险因素的右心房和左心房功能障碍:英国生物库研究

Vidhushei Yogeswaran^1,2, Jennifer A Brody^1,3, Colleen M Sitlani^1,3

¹Cardiovascular Health Research Unit (V.Y., J.A.B., C.M.S., K.L.W., J.B., T.Y., J.S.F.), University of Washington, Seattle.

Circulation. Arrhythmia and electrophysiology

|February 26, 2026

概括

心房心脏病,影响左心房和右心房,独立增加心房动 (AF),中风和心力衰竭的风险. 新的遗传联系和因果关系强调了心房结构在心血管疾病中的作用.

科学领域:

心脏病学心脏病学
遗传学是一个遗传学.
生物标志物生物标志物

背景情况:

心房心脏病是心房动 (AF) 的已知前体,也是心血管事件的危险因素.
以前的研究受到样本大小的限制,并且经常排除右前庭.
了解双心结构和功能对于预测心血管结果至关重要.

研究的目的:

评估左和右心房结构和功能与新发性AF,缺血性中风,心力衰竭和痴呆症的关联.
通过心房测量来识别新的遗传关联.
使用孟德尔随机化研究心房测量和心血管结果之间的因果关系.

主要方法:

利用心脏磁共振成像和深度学习细分在51,693英国生物库参与者没有流行的AF.
评估了双体体积和排空分数.
进行了全基因组关联研究和孟德尔随机化分析.

主要成果:

左心房和右心房的测量都独立地与新发性AF,缺血性中风和心力衰竭的风险增加有关.
左心房最小体积也与痴呆风险有关.
确定了51个与心房尺度的遗传关联,包括27个新的位置,与心脏代谢因素和心血管表型有明显的遗传相关性.

结论:

这项迄今为止最大的双心房结构研究证实了左心房和右心房心脏病与心血管不良事件的独立关联.
新的遗传位置和独特的相关性为室内特定的重塑和心血管疾病途径提供了洞察力.
前庭测量可能是以前仅归因于AF的心血管并发症的因果决定因素.

关键词:

心房动是心房动的一种.心血管疾病心血管疾病深度学习是一种深度学习.心脏的前庭是心脏的前庭.心脏衰竭是因为心脏衰竭.

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