在重大紧急腹部手术后早期或推迟的辅助腹腔营养 (The EATERS试验):协议和统计分析计划
Jannick B Hansen1,2, Dunja Kokotovic1, Lau C Thygesen3
1Department of Gastrointestinal and Hepatic Diseases, Copenhagen University Hospital - Herlev-Gentofte; Emergency Surgery Research Group Copenhagen (EMERGE Cph), Copenhagen University Hospital - Herlev-Gentofte, Herlev, Denmark.
The British journal of nutrition
|February 26, 2026
概括
早期补充腹腔营养 (PN) 可以减少急诊腹部手术患者的术后感染. EATERS试验调查了最佳PN时间,以改善这一高风险组的结果.
科学领域:
- 手术营养是指手术营养.
- 关键护理医学 关键护理医学
- 临床试验 临床试验
背景情况:
- 亲肠道营养 (PN) 在口服或肠道摄入不足时至关重要.
- 对于紧急手术患者的PN时间存在有限的证据.
- 在这个人群中,手术后感染是一个很大的问题.
研究的目的:
- 评估早期补充PN对术后感染的影响.
- 在重大紧急腹部手术中,比较早期PN启动与延迟PN.
- 为高风险手术患者的PN管理提供基于证据的指导.
主要方法:
- 一个多中心,随机对照试验 (EATERS试验) 涉及342名成年患者.
- 随机分配给从术后第二天 (POD) 或POD5开始接受PN的患者.
- 主要结局:手术后医院感染的发生率;次要结局包括并发症,停留时间和死亡率.
主要成果:
- 这项研究旨在为PN时间提供新的见解.
- 盲目的结果评估和治疗意向分析将确保可靠的研究结果.
- 结果将为临床实践提供有关早期营养支持的信息.
结论:
- EATERS试验旨在澄清早期PN在紧急腹部手术后减少感染中的作用.
- 这些发现将提高透明度,减少外科营养研究中的偏见.
- 这项研究将为优化患者康复和结果提供有价值的数据.
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