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Updated: Feb 27, 2026

Rare Event Detection Using Error-corrected DNA and RNA Sequencing
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从基因组学到结构:通过LOOCV验证的集体学习,TP53DNA结合核心中的进化和临床信号

Syed Raza Abbas1, Zeeshan Abbas1,2, Arifa Zahir3

  • 1Department of Precision Medicine, Sungkyunkwan University, School of Medicine, Suwon 16419, Republic of Korea.

Briefings in bioinformatics
|February 26, 2026
PubMed
概括

了解TP53瘤抑制剂的进化约束是解释其致病变体的关键. 这项研究通过整合进化基因组学,结构生物学和临床数据来确定关键的TP53残留物,包括代码子129和残留物239-248.

关键词:
阿尔法折叠是什么意思阿尔法折叠的DNA结合域域.这就是TP53的特点.生物信息学是一种生物信息学.编码器意识到对齐的情况进行比较的基因组学.组合学习组合学习阳性选择是一种积极的选择.

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