在普通话说的美国老年人中开发和验证新的认知测试
William T Hu1,2, Michelle H Chen1,2, Mei-Ling Li1,2
1Department of Neurology, Robert Wood Johnson Medical School, Rutgers Biomedical and Health Sciences, New Brunswick, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|February 26, 2026
概括
验证的普通话认知测试有助于在华裔美国人中早期发现阿尔茨海默病 (AD). 这些文化相关的工具显示出高可靠性,并与认知障碍标志物相关联.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 老年学是一门学科.
背景情况:
- 中国普通话说者是世界上最大的群体,但在多元文化环境中对阿尔茨海默病 (AD) 的认知测试很少.
- 早期和准确的AD检测至关重要,特别是在多样化的人口中.
研究的目的:
- 开发和验证普通话认知测试,以评估老年人的记忆,执行功能和语言.
- 评估这些新型测试在美国多元文化环境中的可靠性和有效性.
- 探索认知表现与阿尔茨海默病生物标志物之间的关联.
主要方法:
- 适应和开发普通话认知测试,包括新的流利性任务 (字符,语音,同音).
- 预计在美国两个中心招募208名老年人.
- 测试重复测试可靠性,融合性,构造性和并发性有效性的评估,以及因子分析和生物标志物相关性 (血p-Tau217).
主要成果:
- 对于所有普通话认知指标,观察到高的测试重复测试可靠性 (ICC 0.6800.849).
- 因子分析确定了16个认知指标的六个潜在因素.
- 异常的执行功能或故事记忆测试与轻度认知障碍和血p-Tau217.217升高有关.
结论:
- 经过验证的普通话认知措施为早期AD检测提供了文化和语言上适当的工具.
- 这些测试对于识别老年华裔美国人的认知衰退是有价值的.
- 该研究强调了文化敏感认知评估在阿尔茨海默病研究中的重要性.
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