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用于细分大腿骨和小腿骨重建的患者特异性晶格植入物 (第一部分):缺陷模式,固定策略和重建选项-一篇评论

Mansoureh Rezapourian¹, Anooshe Sadat Mirhakimi², Mahan Nematollahi³

¹Department of Mechanical and Industrial Engineering, Tallinn University of Technology, 19086 Tallinn, Estonia.

Biomimetics (Basel, Switzerland)

|February 26, 2026

概括

使用计算机断层扫描 (CT) 和增材制造 (AM) 制造的患者特定的多孔植入物显示出重建大型骨缺陷的前景. 然而,模拟和临床结果之间存在很大的验证差距,这阻碍了广泛采用.

科学领域:

整形外科手术整形外科手术
生物材料科学是生物材料的科学.
医疗器械工程医疗器械工程

背景情况:

股骨和骨中的大型细分缺陷带来了重大的重建挑战.
基于计算机断层扫描 (CT) 的,增材制造 (AM) 的多孔植入物提供了针对患者的具体解决方案.
目前的方法利用晶格植入物,架构子和具有工程孔隙性的模块化结构.

研究的目的:

审查基于CT的AM多孔植入物用于股骨和骨重建的应用.
分析缺陷特征如何影响固定和机械性能.
确定当前的局限性和临床翻译的未来方向.

主要方法:

关于使用基于CT的AM多孔植入物用于长骨重建的研究的综合文献综述.
对缺陷分类,植入物设计,固定策略和报告结果的分析.
模拟 (有限元分析) 和机械测试数据的评估.

主要成果:

结果受到缺陷形态学和当地生物学的强烈影响.
植入物刚性,微运动和疲劳是由格子架构,相对密度和固定控制的.
在模拟/实验室测试和体内验证之间存在很大的差距,对生物终点的报告有限.

结论:

基于CT的AM多孔植入物显示出对细分骨缺陷重建的潜力.
缺陷描述符,固定报告和结果指标的标准化至关重要.
通过集成的数据集和协调的协议来弥合验证差距对于临床翻译至关重要.

关键词:

通过3D打印的多孔支架.基于CT的外科规划在整形医疗中添加剂制造.关键大小的骨缺陷关键大小的骨缺陷腿部和小腿骨的重建固定策略固定策略晶格植入物是一种晶格植入物承载载荷的承载载载荷的锁定板固定固定方式锁定板固定方式机械生物学机械生物学患者特定的植入物植入物.个性化骨组织工程个性化骨组织工程多孔的骨架架构的骨架架构.由脚手架引导的骨再生细分的股骨和骨缺陷.细分长骨缺陷细分长骨缺陷应力屏蔽应力屏蔽

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