热处理的乳糖菌株 (Lacticaseibacillus rhamnosus) 在体外系统中调节炎症和代谢过程,这与犬类骨关节炎有关
Laura Rago1, Guillermo García-Lainez1, Miren Maicas1
1Archer Daniels Midland, Nutrition, R&D Health & Wellness, Biopolis S.L. Parc Cientific Universitat de València, C/Catedrático Agustín Escardino Benlloch, 9, 46980 Paterna, Spain.
Cells
|February 26, 2026
概括
两种新的后生物候选药物,PRIOME® JH和HT-PB01,来自Lacticaseibacillus rhamnosus,通过减少炎症和支持关节健康,显示出对抗狗骨关节炎的希望.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 狗骨关节炎是一种退行性关节疾病,导致疼痛和功能障碍.
- 目前的治疗方法侧重于症状管理,而不是潜在的生理问题.
- 诸如炎症,肉症和肠道健康等因素有助于骨关节炎的风险.
研究的目的:
- 确定用于犬类关节健康的新型后生物候选者.
- 评估特定细菌菌株的抗炎和冠状腺保护作用.
- 研究后生物药物减轻骨关节炎风险因素的潜力.
主要方法:
- 选了9种经过热处理的细菌菌株的抗炎活性.
- 评估了两种Lacticaseibacillus rhamnosus菌株 (PRIOME® JH,HT-PB01) 在犬类冠状细胞和巨细胞上.
- 利用Caenorhabditis elegans模型来评估对肠道健康,脂肪积累和肉症的影响.
主要成果:
- PRIOME® JH和HT-PB01对犬类冠状细胞表现出显著的抗炎作用.
- 这些菌株增加了II型原蛋白合成,并调节了巨细胞中的免疫反应.
- 临床前模型表明,有可能减少肠道炎症,改善肠道透性,减轻肉症.
结论:
- 普里奥姆® JH和HT-PB01是对狗骨关节炎有前途的后生物候选药物.
- 这些后生物药通过多种机制向多种风险因素.
- 需要在狗身上进行进一步的临床试验来证实疗效.
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