口服益生菌对儿童的Streptococcus mutans的影响:系统性审查和元分析
Andrea Caiza-Rennella1,2, Andrea Ordoñez-Balladares1, Rosangela Caicedo-Quiroz1
1Carrera de Odontología, Universidad Bolivariana del Ecuador, Duran 092406, Ecuador.
Dentistry journal
|February 26, 2026
概括
口服益生菌如Lactobacillus reuteri和Lactobacillus rhamnosus可能会在短期内降低儿童中的Streptococcus mutans. 缓慢溶解的配方显示出最一致的效果,但需要更多的研究来确定长期益处.
科学领域:
- 微生物学 微生物学
- 儿科牙科 儿科牙科
- 预防医学 预防医学
背景情况:
- 幼儿脏病与口腔失生症和Streptococcus mutans的扩散有关.
- 口服益生菌,特别是Lactobacillus reuteri和Lactobacillus rhamnosus,正在研究调节菌微生物.
- 这些益生菌可能提供一种减少S. mutans在儿童口腔微生物群中的策略.
研究的目的:
- 系统地审查和元分析口服Lactobacillus reuteri和Lactobacillus rhamnosus在降低唾液中S. mutans水平方面的疗效.
- 评估这些益生菌对6个月至12岁儿童的影响.
- 评估配方和持续时间对益生菌有效性的影响.
主要方法:
- 按照PRISMA 2020指南进行系统审查和元分析.
- 在主要数据库 (MEDLINE/PubMed,CENTRAL,Embase,Scopus,LILACS) 进行无限制的搜索.
- 包括随机对照试验 (RCT) 与≥30天的益生菌管理;偏差风险和证据的确定性评估使用RoB 2和GRADE.
主要成果:
- 包括六个RCT (N=1362) 在内. 两项试验的元分析显示,唾液S.突变菌的显著减少 (MD = -0.65 log10 CFU/mL; p < 0.0001),尽管由一项研究驱动.
- 对四项试验进行的二分分析表明,风险降低的趋势不显著 (OR = 0.73; p = 0.10).
- 使用高口服保留率配方的短期干预显示出最一致的微生物效应.
结论:
- 口服益生菌显示出可能在短期内显著减少唾液S. mutans,特别是缓解的配方.
- 疗效因益生菌菌株,输送载体和干预时间而异.
- 进一步的大规模,标准化,长期试验是必要的,以确认持续的临床益处.
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