外节NK/T细胞淋巴瘤,鼻类型,呈现为单独的口腔表现
Andrea Kanizsai1, Ágnes Bán2, László Kereskai3
1Maxillofacial Division, Oral and Maxillofacial Surgery, Department of Dentistry, Medical School, University of Pécs, Rákóczi Street 2, H-7623 Pécs, Hungary.
Dentistry journal
|February 26, 2026
概括
外节NK/T细胞淋巴瘤,鼻类型,以口腔病变的形式呈现,具有诊断挑战,模仿良性疾病. 早期活检和多学科合作对于及时诊断和改善这种罕见淋巴瘤的结果至关重要.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 外节NK/T细胞淋巴瘤,鼻类型 (ENKTCL-NT) 是一种罕见的,侵袭性的非霍奇金淋巴瘤.
- 主要口腔表现不常见,经常模仿传染病或牙病,延迟诊断.
研究的目的:
- 报告一个独特的ENKTCL-NT病例,仅以破坏性口腔病变的形式呈现.
- 突出诊断方面的挑战,并强调早期全面评估的重要性.
主要方法:
- 一名患有口腔的32岁男性接受了成像 (PET-CT),活检,组织病理学,免疫组织化学,EBV检测 (EBER ISH) 和TCRG基因重组分析.
- 通过非典型的淋巴细胞透,血管中心生长,特异性免疫表型 (CD56+,EBV+) 和单克隆TCRG重排证实了诊断.
主要成果:
- 口腔病变是性,出血性,由二次感染复杂化,并显示了异型淋巴细胞的广泛亡.
- 瘤细胞是CD56 +,EBV +,具有高增殖率 (Ki-67). PET-CT显示了局部侵入性,FDG-狂热的病变.
- 最初的治疗 (化疗 + 放射治疗) 产生了部分反应,但患者后来复发了耐火性疾病.
结论:
- 隔离口服ENKTCL-NT具有重大诊断挑战,因为它模仿良性疾病.
- 持续的口腔病变需要考虑血液恶性瘤,需要立即进行活检和多学科输入.
- 通过全面的测试和协作进行准确的诊断对于可能改善罕见ENKTCL-NT表现的结果至关重要.
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