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基于多材料挤出的混合脚手架的3D打印用于组织工程应用.

Andrey Abramov1, Yan Sulkhanov1, Natalia Menshutina1

  • 1Department of Chemical and Pharmaceutical Engineering, Mendeleev University of Chemical Technology of Russia, Miusskaya pl. 9, 125047 Moscow, Russia.

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概括

本研究介绍了一种新的3D打印平台,用于使用水凝和热塑性塑料创建混合脚手架. 该系统确保精确的材料沉积,用于先进的组织工程应用.

关键词:
直接墨水写作 (DIW) 是指直接墨水写作.基于挤压的3D打印技术.水凝油墨是使用水凝油墨的.水凝热塑混合动力支架 热塑混合动力支架多种材料的3D打印.可打印性和剂量的准确性.过程参数 过程参数组织工程是组织工程.

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科学领域:

  • 生物材料工程 生物材料工程
  • 增材制造 增材制造 增材制造
  • 组织工程是组织工程.

背景情况:

  • 水凝支架的增材制造需要精确控制材料特性和挤出.
  • 多材料架构在控制质和沉积动态方面提出了独特的挑战.

研究的目的:

  • 开发一个模块化,多材料的3D打印平台,用于制造混合水凝-热塑性脚手架.
  • 实施经验校准程序,用于精确的凝剂量在挤出式印刷.

主要方法:

  • 一个模块化平台,结合了丝和活塞驱动的挤出机被开发出来.
  • 一个实证校准算法优化了剪切稀释酸盐凝的挤出参数 (EPr/R).
  • 制造了两种混合结构:用聚烯酸框架的酸盐支架和酸盐-酸盐复合结构.

主要成果:

  • 校准算法将沉积质量差异降低到容忍值以下.
  • 在交叉连接和溶剂处理后,成品结构显示出机械稳定性.
  • 3D打印的脚手架通过冷或超临界干燥成功转化为高度多孔的结构.

结论:

  • 开发的系统可以实现可重复的多材料3D打印水凝-热塑性混合脚手架.
  • 硬件和校准方法可以适应用于组织工程的各种基于凝的油墨.
  • 这项技术有助于为再生医学创建复杂的支架.