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精液中介质素-6作为炎症,氧化应激和不育男性精子功能障碍的生物标志物

Loïc Koumba^1,2,3, Mariame Kabbour^2,3,4, Salma Ed-Doumy¹

¹Laboratory of Health, Environment and Biotechnology, Team of Physiopathology, Molecular Genetics and Biotechnology, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, B.P 5366 Maarif, Casablanca 20100, Morocco.

Diseases (Basel, Switzerland)

|February 26, 2026

概括

精液中介质素-6 (IL-6) 与精子质量降低和不孕男性氧化应激增加有关. 较高的IL-6水平表明潜在的炎症和精子功能障碍,这表明它可以作为临床生物标志物使用.

科学领域:

生殖医学生殖医学
免疫学免疫学免疫学
氧化压力研究研究氧化压力研究

背景情况:

介乐-6 (IL-6) 是一种在精液中发现的细胞因子,即使没有感染.
它在精子功能障碍,氧化应激和炎症中的作用尚未完全理解.
研究IL-6对男性不孕症标志物的影响至关重要.

研究的目的:

评估精液IL-6度与精液质量之间的关联.
评估IL-6与氧化应激标志物,核完整性和不孕男性炎症之间的关系.

主要方法:

分析了204名不育的男性.
测量了种子IL-6,精液参数,甲基 (MDA),催化酶 (CAT) 活性,精子DNA碎片化指数 (DFI),精子染色体脱凝指数 (SDI),白细胞精子和细菌精子.
使用了电化学发光免疫测试,相关性测试,IL-6值分层和多变量回归.

主要成果:

所有样本都显示出可检测的IL-6 (中位数:31.52ppg/mL).
较高的IL-6与精子度,运动性,活力降低以及DFI,SDI,MDA,白细胞和细菌精子 (p < 0.001) 的增加相关.
独立地预测IL-6减少了运动性和白细胞升高,并增加了DFI,SDI和细菌精子症的几率 (p <0.05).

结论:

精液IL-6是免疫氧化应激和不孕男性精子功能障碍的敏感生物标志物.
测量精子IL-6可以提高对导致男性不孕症的炎症和氧化因素的评估.

关键词:

细菌精子症是一种细菌精子症.血清细胞精子缺陷血清细胞精子缺陷男人的不孕不育症.氧化应激是一种氧化应激.种子 IL-6 的 IL-6 种子.精子DNA碎片化精子DNA碎片化精子染色素脱凝精子染色素脱凝精子质量精子质量精子质量

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