细胞表型和病理体的诊断价值使用尿流细胞计在患有狼性炎的儿童
Ferdy Royland Marpaung1,2, Risky Vitria Prasetyo2,3, Anggia Augustasia Lumban Toruan4
1Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia.
Diseases (Basel, Switzerland)
|February 26, 2026
概括
异形红细胞 (DysRBC),管状上皮细胞 (RTEC) 和病理体 (PathCasts) 在诊断儿童狼性炎 (LN) 方面表现有前途. 特别是DysRBC在本研究中表现出卓越的诊断价值.
科学领域:
- 儿科脏病学 儿科脏病学
- 尿流细胞计 尿流细胞计
- 诊断生物标志物 诊断生物标志物
背景情况:
- 淋巴细胞和管状异常是狼性炎 (LN) 的关键.
- 尿路异形红细胞 (DysRBC) 表明球损伤.
- 管状上皮细胞 (RTEC) 和病态体 (PathCasts) 表明管损伤.
研究的目的:
- 评估尿路DysRBC,RTEC和PathCast在患有狼性炎的儿童的诊断性能.
- 评估尿流细胞计对检测这些尿路标记物的有用性.
主要方法:
- 分析了来自317名儿科患者的尿样.
- 采用接收器操作特征 (ROC) 分析来确定诊断价值.
主要成果:
- 所有测试的参数都显示了可接受的歧视性性能.
- %DysRBC具有优异的诊断值 (AUC = 0.954,p < 0.001). 这是一个非常好的诊断值.
- 同样,RTEC (AUC = 0.580,p = 0.001) 和PathCast (AUC = 0.664,p = 0.001) 的诊断价值也显著.
结论:
- 尿路DysRBC,RTEC和PathCasts可能有助于诊断儿科狼性炎.
- %DysRBC作为区分LN的生物标志物特别有前途.
- 需要进一步的大规模研究来验证这些发现.
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