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Updated: Feb 27, 2026

Author Spotlight: Advancing SERS Technology: Au@Carbon Dot Nanoprobes for Label-Free Analysis and Imaging

Author Spotlight: Advancing SERS Technology: Au@Carbon Dot Nanoprobes for Label-Free Analysis and Imaging

Published on: June 9, 2023

开发具有高灵敏度表面增强拉曼散射成像探测器性能的生物窗口活性开外纳米粒子.

Kosuke Sugawa¹, Yuka Hori², Azusa Onozato¹

¹Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Chiyoda 101-8308, Tokyo, Japan.

Nanomaterials (Basel, Switzerland)

|February 26, 2026

概括

研究人员开发了用于近红外 (NIR) 成像的金色开纳米粒子 (AuOSN). 这些生物相容的纳米颗粒显示出强大的表面增强拉曼散射 (SERS) 活性,使细胞可视化无毒表面活性剂.

关键词:

生物成像是一种生物成像.局部化的表面等离子体纳米子是一种纳米.开放的纳米结构.表面增强的拉曼散射作用

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科学领域:

纳米技术纳米技术
生物医学工程生物医学工程
材料科学材料科学材料科学

背景情况:

不同类型的金纳米结构对于诊断和治疗纳米技术至关重要.
近红外 (NIR) 生物窗口中的局部表面等离子体 (LSP) 共振具有显著的兴趣.

研究的目的:

开发具有强大的NIR SERS活性的金色开纳米粒子 (AuOSNs).
为SERS传感和细胞成像创建一个生物相容且无表面活性剂的平台.

主要方法:

使用无表面活性剂的策略制造AuOSN,该策略结合了自下而上的球组装和自上而下的黄金沉积.
边界元素方法 (BEM) 模拟用于分析电磁场定位.
用4 - 默卡普托酸 (4-MBA) 和聚乙烯糖醇 (PEG) 修改的AuOSN的LSP共振和SERS活性的表征.

主要成果:

在开口边缘附近,AuOSN表现出强烈的NIR LSP共振,峰值在793nm.
用4-MBA修改的AuOSN显示出高的SERS增强因子 (~10^6).
经PEG修饰的AuOSN显示出微不足道的细胞毒性,并使HeLa细胞的SERS成像成为可能.

结论:

没有表面活性剂的AuOSN为NIR激发的SERS传感提供了一个生物相容的平台.
AuOSN显示了等离子体生物成像应用的巨大潜力.
破坏对称性的纳米架构有效地诱导NIR LSP共振,以增强SERS活动.