侵入性肺部真菌感染中的生物标志物:我们站在哪里?
Isabel Montesinos1, Hector Rodriguez-Villalobos1
1Microbiology Department, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, 1200 Brussels, Belgium.
Journal of fungi (Basel, Switzerland)
|February 26, 2026
概括
在重症患者中早期检测入侵性肺性真菌感染至关重要. 新的生物标志物如银河,β-D-葡萄糖和PCR测试可以改善诊断,但在它们的最佳使用和解释方面仍然存在挑战.
科学领域:
- 医学真菌学 医学真菌学
- 临床诊断 临床诊断 临床诊断
- 传染性疾病 传染性疾病
背景情况:
- 侵袭性肺部真菌感染在免疫功能低下的患者中引起显著的发病率和死亡率.
- 传统的诊断方法 (培养,组织病理学) 在灵敏度和速度上有局限性.
- 新兴的生物标志物为更早,更准确的检测提供了潜力.
研究的目的:
- 审查目前关于肺部真菌感染生物标志物的最佳使用的证据.
- 突出解释特定病原体和患者群体的诊断测试的挑战.
- 讨论组合生物标志物在提高诊断准确性的作用.
主要方法:
- 对银河,β-D-葡萄糖和PCR测定现有证据的审查.
- 基于病原体,样本类型和宿主群体的生物标志物性能分析.
- 讨论生物标志物解释的挑战和策略.
主要成果:
- 血清学和分子生物标志物显示出早期检测阿斯伯吉洛症和肺细胞瘤的前景.
- 粘膜菌的诊断工具是有限的.
- PCR分析具有潜力,但面临实施和标准化挑战.
- 预计将有基于抗原的测试可供使用.
结论:
- 生物标志物的最佳使用需要了解它们的优点,局限性和性能变化.
- 结合生物标志物可以提高诊断准确度,并指导及时的治疗决策.
- 鉴于复杂的宿主因素,不断发展的真菌流行病学和扩大治疗选择,准确的解释至关重要.
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