宏壮壮症的治疗之旅:一个单中心研究
Varvara Chalmantzi1, Sophia Vlachou2, Maria Eleni Chondrogianni2
1Unit of Endocrinology, First Department of Internal Medicine, Laikon Hospital, 11527 Athens, PC, Greece.
Journal of personalized medicine
|February 26, 2026
概括
在大多数壮病患者中,生物化学控制是可以实现的,但更高的IGF-1/ULN比率可能预测非缓解. 年长的患者经历了更长的诊断延迟,并且不太可能接受手术.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
背景情况:
- 巨症的治疗已经进步,但生化控制仍然是许多患者面临的挑战.
- 个性化医疗方法正在发展,但大量的壮病患者仍然缺乏最佳的疾病管理.
研究的目的:
- 系统地分析患者在巨的旅程,专注于腺瘤特征,治疗和并发症.
- 专门研究年龄对壮症诊断,治疗和结果的影响,重点关注老年患者.
主要方法:
- 对79名在1971年至2023年期间被诊断为壮病的患者进行了回顾性研究.
- 数据收集包括腺瘤特征,治疗干预 (手术,医疗,放射治疗) 和疾病结果.
主要成果:
- 85%的患者实现了疾病缓解,生物化学控制是最常见的结果.
- 诊断时IGF-1/ULN比率较高倾向于预测非缓解.
- 较长的诊断延迟 (>5年) 与诊断时的年龄较大 (58±6年) 有关.
- 与年轻患者相比,在60岁以上被诊断出来的患者不太可能接受手术.
结论:
- 生物化学控制是壮症管理的常见结果.
- 诊断时IGF-1/ULN水平升高可能表明缓解的预后较差.
- 晚年与延迟诊断和壮病患者手术干预的可能性降低有关.
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