纳入人工唾液中的抗菌剂的评估:对白虫的分析
Camila Alves Carneiro1,2, Fenelon Martinho Lima Pontes3, Karin Hermana Neppelenbroek1
1Department of Prosthodontics and Periodontics, Dental School of Bauru, University of São Paulo, Bauru 17000-000, SP, Brazil.
Journal of functional biomaterials
|February 26, 2026
概括
人工唾液 (AS) 与尼斯塔丁 (Nys),赫西丁 (Chx) 或银纳米颗粒 (AgNp) 有效抑制了Candida albicans生物膜. Nys,Chx和高度的AgNp显示出显著的抗真菌活性,改善了口腔健康潜力.
科学领域:
- 口腔健康 口腔健康
- 生物材料科学 生物材料科学
- 微生物学 微生物学
背景情况:
- 唾液对口腔健康至关重要;低唾液含量会增加疾病风险.
- 抗微生物人造唾液 (AS) 配方正在探索与口腔疾病作斗争.
- 在口腔环境中,Candida albicans生物膜构成重大威胁.
研究的目的:
- 评估含有尼斯塔丁 (Nys),素 (Chx) 和银纳米颗粒 (AgNp) 的AS的抗菌疗效.
- 为了确定最小抑制度 (MIC) 和最小杀菌度 (MFC) 针对Candida albicans生物膜.
- 评估这些AS配方对假牙材料生物膜发育的影响.
主要方法:
- 测试了六种AS配方:单独的AS,具有不同AgNp度的AS (2,4,6毫米),AS + Nys和AS + Chx.
- 使用XTT色度测定方法评估菌和杀菌性质.
- 在3,6和12小时的时间里,在烯酸树脂样本上培养了Candida albicans生物膜,通过CFU/mL计数量化.
主要成果:
- 所有测试的AS配方都显示出明显抑制真菌负荷和降低代谢活性 (p < 0.05).
- 含有Nys,Chx和6mM AgNp的AS配方对C. albicans生物膜表现出类似且显著的抑制作用.
- 与对照组相比,在实验组中观察到生物膜生长的显著减少.
结论:
- 人工唾液中的尼斯塔丁,赫西丁和高度银纳米颗粒对Candida albicans生物膜有效.
- 这些增强的AS配方对治疗口腔角膜炎和改善低水患者的口腔健康有前途.
- 进一步的研究可以探索这些强效抗微生物AS配方的临床应用.
相关概念视频
01:18Surface Membrane Barriers
3.1K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
3.1K
01:28Antimicrobial Effectiveness
1.3K
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
1.3K