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在人类牙培养模型中评估基于酸的酸盐水泥的组织组织反应:系统性审查

Alberto Cabrera-Fernández¹, Hebertt Gonzaga Dos Santos Chaves², Aránzazu Díaz-Cuenca³

¹Department of Stomatology, Endodontic Section, School of Dentistry, University of Sevilla, 41009 Sevilla, Spain.

Journal of functional biomaterials

|February 26, 2026

概括

基于酸盐的液压水泥 (CSCs) 显示了生物相容的纸反应,并促进了人类牙培养物中牙修复的矿化. 树脂修饰的CSC表现出更可变的组织学结果,这表明修复潜力的差异.

科学领域:

生物材料科学生物材料科学
牙科研究牙科研究
历史学历史学历史学

背景情况:

活体人类牙培养模型对于研究对生物材料的牙-真皮复杂反应是有价值的.
纸封闭旨在保持纸活力,并在暴露后促进牙桥形成.

研究的目的:

在ex vivo人类牙培养模型中,系统地审查酸基水泥 (CSCs) 的组织组织组织组织反应,用于直接封盖.

主要方法:

按照PRISMA 2020指南进行系统审查.
包括使用ex vivo人类牙培养物的研究,直接暴露于用CSCs治疗的肉质,并报告组织学结果.
使用QUIN工具进行偏差风险评估.

主要成果:

包括13项研究,主要使用未成熟的人类第三牙,培养期长达90天.
液压CSCs (例如Biodentine,ProRoot MTA) 始终表现出生物相容性和诱导矿化 (骨质样组织).
与液压CSC相比,树脂修饰的CSC (例如,TheraCal LC) 显示出可变且往往不那么突出的矿化.

结论:

液压CSC表现出可复制的生物相容性,并在人类牙培养模型中促进修复性牙生成.
树脂修饰的CSC在这些模型中呈现出更可变的组织学性能.
活体人类牙培养物为评估纤维质封闭生物材料提供了一个翻译平台.

关键词:

生物牙是一种生物牙.基于酸的水泥是基于酸的水泥.牙纸的封闭方式人类牙文化模型修复性牙可以修复牙.有关生命脉的治疗.

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