子周长作为一种实用的人类测量生物标志物,用于2型糖尿病中的内脏肥胖和代谢失调
Meixia Ji1, Zhifu Zeng1, Zhengliang Huang2
1Lishui People's Hospital, Lishui 323000, China.
Metabolites
|February 26, 2026
概括
子周长 (NC) 有效估计内脏脂肪面积 (VFA) 和2型糖尿病 (T2D) 的代谢风险. 性别特定的NC切断线提供了一个简单的工具,用于识别需要对代谢疾病进行早期干预的个体.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 临床诊断 临床诊断 临床诊断
背景情况:
- 内脏脂肪组织 (VAT) 在2型糖尿病 (T2D) 中显著推动胰岛素抵抗和失糖症.
- 准确的临床评估的增值税仍然是一个重要的挑战在日常医疗保健.
- 需要新的,实用的生物标志物,以便在T2D患者中有效地进行代谢风险分层.
研究的目的:
- 验证子周长 (NC) 作为用于估计内脏脂肪面积 (VFA) 的实际人体测量生物标志物.
- 评估NC在确定T2D队列内与内脏脂肪相关的代谢风险方面的实用性.
- 为改善查和早期干预策略建立性别特定的NC截止值.
主要方法:
- 一项涉及1139名T2D患者的横截面研究.
- 通过生物电阻分析收集NC,生物化学参数和VFA/皮下脂肪区域 (SFA) 的数据.
- 利用皮尔森的相关性,多变量逻辑回归和ROC曲线分析进行验证和切线确定.
主要成果:
- NC与VFA (p < 0.001),BMI,WHR和SFA有很强的正相关性.
- 在男性中,NC与禁食胰岛素,胰岛素抵抗指数,甘油三和肌素正相关.
- 确定了异常VFA的最佳性别特定切线点:NC> 39.5厘米男性和> 35.5厘米女性.
结论:
- 子周长是T2D中内脏脂肪的高度可访问和有效的生物标志物.
- 建立的性别特异性NC截止值为风险分层提供了一个简单的,非侵入性的工具.
- 在临床和公共卫生环境中,NC有助于早期干预和改善代谢功能障碍的管理.
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