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循环CCDC3作为2型糖尿病患者内脏脂肪积累的指标

Lin Zhu¹, Xiaodie Fan¹, Jiangang Lu²

¹Department of Medical Experimental Technology, College of Basic Medicine, Obesity and Metabolic Diseases Research Center, Chongqing Medical University, Chongqing 400016, China.

|February 26, 2026

概括

循环环绕圈域含有蛋白3 (CCDC3) 显示出作为血液生物标志物,用于2型糖尿病 (T2DM) 的内脏脂肪. 较高的CCDC3水平与增加的内脏脂肪度相关,有助于更好的患者表型.

科学领域:

内分泌学在内分泌学.
代谢综合征是代谢综合征的一种.
生物标志物发现发现

背景情况:

内脏脂肪是2型糖尿病 (T2DM) 中心脏代谢风险的关键.
目前的评估依赖于成像或间接措施,限制了临床效用.
需要可访问的血液标记物来改善T2DM表型.

研究的目的:

作为内脏脂肪积累的潜在生物标志物,研究卷状卷域含蛋白3 (CCDC3).
评估T2DM成年人中循环CCDC3水平和内脏脂肪区域 (VFA) 之间的关联.

主要方法:

对RNA测序数据和脂肪组织的分析确定CCDC3是富含内脏脂肪的.
使用双能X射线吸收计对160名T2DM成年人的横截面研究.
血CCDC3通过ELISA测量;使用多变量和逻辑回归,ROC,DCA和SHAP分析了与VFA的关联.

主要成果:

血CCDC3水平与VFA正相关 (β = 3.11,p < 0.001),独立于其他因素.
包括CCDC3改善了腹部肥胖的歧视 (AUC为0.820与0.663,p=0.009).
CCDC3在腰围等传统指标之外显示出显著的增量重要性.

结论:

循环中的CCDC3可以作为一种有价值的血液生物标志物,用于T2DM中的内脏脂肪.
CCDC3为评估心脏代谢风险的人类测量措施提供了补充信息.
这一发现支持T2DM患者的增强表型和风险分层.

关键词:

CCDC3 疾病预防控制中心腹部肥胖症腹部肥胖症循环生物标志物循环生物标志物 2型糖尿病是什么?内脏脂肪区域的内脏脂肪区域.

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