结直肠印米他辛加乳酸林格斯用于儿童ERCP后胰腺炎的预防
1Department of Pediatric Gastroenterology, Çukurova University School of Medicine, Adana, Turkey.
Acta gastro-enterologica Belgica
|February 26, 2026
概括
这项研究发现,结合直肠印米他辛和乳酸林格斯 (LR) 对于接受内镜逆行胆血管瘤学 (ERCP) 的儿科患者来说是安全的. 然而,这种预防措施并没有显著降低ERCP后胰腺炎 (PEP) 或胆管炎的发病率.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 内镜手术 进行内镜手术
- 药理学预防 药理学预防
背景情况:
- 有限的儿科数据存在于ERCP后胰腺炎 (PEP) 的预防.
- 这项研究解决了在接受ERCP的儿童中需要有效的PEP预防策略的需求.
研究的目的:
- 为了评估结合直肠印梅他辛和乳酸林格斯 (LR) 预防方案的有效性和安全性.
- 评估本协议对儿科ERCP患者的PEP和胆脉炎率的影响.
主要方法:
- 在单一的三级中心 (2012-2025) 进行儿科ERCP的回顾性审查.
- 对2021年后实施的标准化预防方案 (直肠印梅他辛+LR) 与对照组 (2021年之前) 的比较.
- 分析包括PEP,胆管炎,程序复杂性,支架使用,和天真的乳头状况.
主要成果:
- 分析了75名儿童的95个ERCP (预防组:38个程序;对照组:65个程序).
- 预发性皮肤炎的发病率为13.2% (预防) 与13.8% (对照) (p=1.000);结肠炎的发病率为5.3%与7.7% (p=1.000).
- 综合疗法是可行的,耐受性良好,并且没有与治疗相关的不良事件相关.
结论:
- 结合直肠印梅他辛和LR是安全的和可行的儿科ERCP预防.
- 这种疗法并没有显著降低研究队列中的PEP或胆结炎率.
- 需要进行更大的多中心儿科试验,以建立最佳的PEP预防策略.
相关概念视频
Endoscopic Procedures V: ERCP
4.4K
Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
Patient...
Patient...
4.4K
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
1.3K
The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
1.3K
Drugs for Treatment of Constipation-Predominant IBS
987
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
987
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
853
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
853
Chronic Pancreatitis II: Collaborative Care
433
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
433
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents
773
Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
773

