低剂量的脱氧尼瓦伦诱导了断奶小猪的亚临床多器官毒性
Ying Liu1, Sunlin Luo1, Xinchun Zou2
1State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Toxins
|February 26, 2026
概括
小猪料中低剂量的脱氧尼瓦伦醇 (DON) 导致多器官毒性,影响抗氧化能力,免疫功能和生殖激素,尽管没有显著的生长效应. 严格控制料中的DON对小猪健康至关重要.
科学领域:
- 动物科学动物科学
- 毒理学 毒理学 毒理学
- 兽医医学 兽医医学 兽医医学
背景情况:
- 脱氧尼瓦伦醇 (DON) 是谷物谷物中普遍存在的真菌毒素,对牲畜构成风险.
- 在小猪中,DON暴露会导致拒绝料和增长迟缓.
- 低剂量DON暴露的亚临床效应需要系统评估.
研究的目的:
- 为了研究低剂量食DON (0.25-2.0毫克/公斤) 对42天的断奶母猪的影响.
- 评估DON对生长,血液生物化学,抗氧化剂状态,免疫力,肠道健康和生殖的影响.
- 为了确定与DON暴露相关的亚临床毒性标志物.
主要方法:
- 在42天的时间里,用0.25,0.5,1.0和2.0毫克/公斤的净化DON养被断奶的母猪.
- 监测生长表现,分析血清生物化学和免疫标记物.
- 评估抗氧化能力 (T-AOC,MDA),肠道形态 (VH) 和生殖激素 (FSH,LH).
- 对多个器官进行组织病理学检查.
主要成果:
- 在所有DON剂量中对小猪生长表现没有显著影响.
- 观察到亚临床多器官毒性,包括血小板数量减少 (PLT) 和高剂量的ALT升高.
- 抗氧化功能受损 (降低T-AOC,增加MDA) 和抑制IL-10水平.
- 十二指甲状腺高度 (VH) 降低和FSH/LH水平的抑制.
- 肝脏,脏,肠道,子宫和卵巢在1.0-2.0毫克/公斤的DON.
结论:
- 低剂量DON暴露会诱导小猪子临床多器官毒性.
- 无氧化物对抗氧化能力,免疫反应,肠道完整性和生殖激素水平产生负面影响.
- 调查结果强调需要在猪料中进行更严格的DON控制,并在风险评估中考虑亚临床影响.
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