(VI) 调节巨细胞极化和代谢重编程,以损害免疫功能.
Cheng Li1,2, Ruihang Zhang1,2, Yuhan Zhang1,2
1School of Engineering Medicine, Beihang University, Beijing 100191, China.
Toxics
|February 26, 2026
概括
六价 (Cr(VI)) 暴露会改变巨细胞的功能,促进M1极化,损害能量代谢和线粒体完整性. 这突出了Cr (VI) 的存在.
科学领域:
- 免疫毒理学 免疫毒理学
- 环境健康 环境健康
- 细胞的新陈代谢
背景情况:
- 六价 (Cr(VI)) 是一个重要的环境和职业危险影响免疫功能.
- 精确的细胞内在机制的Cr(VI) 诱导的巨细胞变化,包括免疫代谢和线粒体的变化,尚未完全理解.
研究的目的:
- 在实验室中研究Cr (VI) 暴露对巨细胞形态,极化,能量代谢和线粒体完整性的影响.
- 阐明Cr (VI) 引起的免疫毒性背后的细胞内在机制.
主要方法:
- 在实验室中,巨细胞暴露于Cr(VI).
- 对巨细胞形态和M1/M2极化标记物的评估 (TNF-α,CD36,CD80,VEGFb).
- 分析细胞能量代谢 (ATP生产,葡萄糖吸收) 和线粒体功能 (膜潜力,氧化应激).
主要成果:
- 暴露于Cr(VI) 诱导了形态变化和转向M1巨细胞两极分化.
- 关键的M1生物标志物增加,而M2生物标志物在Cr(VI) 暴露后减少.
- 观察到能量代谢受损,ATP生产减少,尽管葡萄糖摄取量较高,但葡萄糖分解增加,以及线粒体损伤.
结论:
- (VI) 暴露会调节巨细胞两极分化和免疫代谢,导致能量产生受损.
- 线粒体功能障碍和氧化应激是Cr (VI) 诱导的巨毒性的关键组成部分.
- 调查结果强调了Cr (VI) 的环境风险和缓解策略的需要.
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