素改善了LPS诱导的免疫应激引起的脂质代谢障碍 在断奶小猪中
Jianlei Zhao1, Wenyi Liu1, Xin Zhang1
1Laboratory of Animal Nutrition Regulation, College of Animal Science and Technology, Nanjing Agriculture University, Nanjing 210095, China.
Veterinary sciences
|February 26, 2026
概括
在断奶小猪中补充素 (CAP) 通过减少脂肪积累和增强脂肪酸氧化,显著改善了脂质代谢. 这种饮食干预还调节了胆固醇合成和胆酸代谢,为动物健康带来了潜在的益处.
科学领域:
- 动物营养 动物营养
- 生物化学 生物化学
- 代谢调节 代谢调节 代谢调节
背景情况:
- 脂质代谢障碍和炎症是断奶小猪的重大问题.
- 中的一种化合物素已经显示出调节新陈代谢过程的潜力.
研究的目的:
- 为了研究素 (CAP) 对断奶小猪的脂质代谢和相关机制的影响.
- 评估CAP对血清脂质,肝脂肪和基因表达的影响.
主要方法:
- 断奶的小猪被食补充素 (4毫克/公斤) 的饮食或基本饮食35天.
- 用脂多糖 (LPS) 诱导炎症,并测量各种脂质参数.
- 分析了与PPARα途径和脂肪酸氧化相关的基因和蛋白质表达.
主要成果:
- 饮食素 (800 mg/kg添加剂) 降低了血清甘油三 (TG),非化脂肪酸 (NEFA) 和肝脏脂肪的积累.
- 在CAP上调节PPARα通路基因/蛋白质,增强脂肪酸氧化.
- CAP调节了胆固醇合成,减少了促炎性脂,并改善了血脂概况 (TC,TG,LDL-C).
结论:
- 素有利于调节血液脂质概况,并扰乱了断奶小猪的脂质代谢-炎症循环.
- 通过TRPV1激活,CAP促进脂肪酸β-氧化和胆酸代谢,减轻肝脏脂质的积累.
- 素显示出改善脂质代谢,肠道健康和免疫功能在断奶小猪的潜力.
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