人类乳头瘤病毒在生殖健康和怀孕:临床影响,结果,和疫苗接种的全面审查
Hasan Volkan Ege1, Charlotte Goutallier2, Laura Burney Ellis3,4
1Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, Faculty of Medicine, Hacettepe University, Ankara 06230, Turkey.
Vaccines
|February 26, 2026
概括
生殖风险与治疗由人类乳头瘤病毒 (HPV) 引起的子宫癌前期癌症有关,而不是与HPV感染本身有关. 接种HPV疫苗是预防的关键,如果在怀孕期间无意中接种,似乎是安全的.
科学领域:
- 妇科瘤学 妇科瘤学
- 传染性疾病 传染性疾病
- 生殖医学 生殖医学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 人类乳头瘤病毒 (HPV) 是一种常见的性传播感染,影响生殖年龄的女性.
- 与HPV相关的疾病及其管理可以显著影响生殖健康和怀孕结果.
- 了解HPV对生育能力,怀孕和新生儿健康的影响对于临床实践和公共卫生至关重要.
研究的目的:
- 审查关于HPV感染和HPV相关疾病的现有证据,涉及生育能力,怀孕和新生儿后果.
- 讨论预防策略,强调HPV疫苗接种的作用.
- 为了告知生育年龄妇女HPV的临床管理.
主要方法:
- 对现有文献进行了叙事审查.
- 来自欧洲妇科瘤学会 (ESGO) 预防委员会的国际多学科团队进行了审查.
- 文献搜索不受时间限制,优先考虑反映HPV,相关疾病,疫苗接种和生殖结果的当前证据的研究.
主要成果:
- 宫癌前期的治疗,特别是切除手术,与早产和怀孕中期流产的风险增加有关.
- 仅HPV感染导致不良怀孕或新生儿后果的证据有限且不一致.
- 关于HPV和不孕不育的数据很少;怀孕期间无意中接种HPV疫苗并没有与不良结果相关.
结论:
- 生殖风险与HPV相关疾病的治疗比与HPV感染本身更强烈相关.
- 接种HPV疫苗对于减少HPV相关疾病的负担至关重要.
- 虽然在怀孕期间不建议常规接种HPV疫苗,但无意中暴露是安全的;长期生殖健康益处需要进一步研究.
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