艾滋病毒感染者HPV疫苗接种方面的进展:一篇综述
Megan Mooberry1, J Brooks Jackson1, Mary B Rysavy2
1Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Vaccines
|February 26, 2026
概括
人类乳头瘤病毒 (HPV) 疫苗接种对于携带艾滋病毒 (PLWH) 的人来说至关重要,他们面临着与HPV相关的癌症的更高风险. 提高这一群体的疫苗接种率对于减少疾病负担至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 人类乳头瘤病毒 (HPV) 是一种常见的性传播疾病,也是各种癌症的主要原因.
- 携带艾滋病毒的人 (PLWH) 患HPV感染和相关癌症的风险更高.
- 在全球范围内,PLWH中存在不理想的HPV疫苗接种覆盖率.
研究的目的:
- 审查HPV流行病学,疫苗免疫性,疗效和PLWH的建议.
- 在PLWH中识别HPV疫苗接种障碍.
- 强调将HPV疫苗接种纳入HIV护理的重要性.
主要方法:
- 关于HPV流行病学的文献综述.
- 在PLWH中分析HPV疫苗免疫性和临床疗效数据.
- 检查当前的疫苗接种指南和障碍.
主要成果:
- 在PLWH中,HPV疫苗是安全的和免疫的,特别是那些具有较高CD4+计数和病毒抑制的疫苗.
- 针对HPV疫苗在减少PLWH中HPV相关疾病的临床疗效数据有限.
- 这些障碍包括剂量表,意识和错误信息.
结论:
- 在PLWH中,HPV疫苗接种是安全有效的,但需要改善覆盖范围.
- 优化疫苗接种计划和解决障碍是关键.
- 将HPV疫苗接种整合到HIV护理中至关重要,以减少与HPV相关的发病率和死亡率.
更多相关视频
13:41Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
13.0K
11:08Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
Published on: February 14, 2025
1.9K
相关概念视频
Cancer Vaccines
1.2K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.2K
Sexually Transmitted Infections
1.3K
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
1.3K
Retrovirus Life Cycles
50.0K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
50.0K
Vaccinations
52.3K
Overview
52.3K
Mechanisms of Retrovirus-induced Cancers
7.1K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
7.1K
